77761-08-1Relevant articles and documents
PAMAM dendrimers functionalized with ruthenium nitrosyl as nitric oxide carriers Metallodendrimers Special Issue
Roveda Jr., Antonio Carlos,Papa, Thiago Bueno Ruiz,Castellano, Eduardo Ernesto,Franco, Douglas Wagner
, p. 147 - 155 (2014)
The functionalization of three generations of polyamidoamine (PAMAM G0, G2 and G3) dendrimers with the NO-donor trans-[Ru(NO)(NH3) 4(ina)](BF4)3 (ina = isonicotinic acid) is reported. PAMAMs were modified through a peptide-type bond between the carboxyl group of the ina ligand and the dendrimer superficial amines. Compounds were characterized by FT-IR, UV-Vis, CV, DPV, 1H NMR, ICP-OES, and the structure of the complextrans-[Ru(NO)(NH3)4(ina)](BF 4)(SiF6)·H2O was determined by single crystal X-Ray analysis. The experimental data indicated the immobilization of 4, ～8 and ～27 nitrosyl complexes on the G0, G2 and G3 dendrimer's surface, respectively, which corresponds to ～1.0-1.43 μmol NO per mg of dendrimer. FT-IR, UV-Vis and electrochemical assays suggest that the functionalization of PAMAM did not alter the coordination sphere of the ruthenium nitrosyl complex neither the formal reduction potential of Ru IINO+/RuIINO0 couple regarding to the complex not attached to PAMAM. The NO release in these compounds, through light irradiation (λ = 355 nm) and one-electron reduction (Eu 2+), was investigated.
Photochemical reactions of trans-[Ru(NH3)4L(NO)] 3+ complexes
Carlos, Rose M.,Ferro, Alessander A.,Silva, Hildo A.S.,Gomes, Maria G.,Borges, Simone S.S.,Ford, Peter C.,Tfouni, Elia,Franco, Douglas W.
, p. 1381 - 1388 (2008/10/09)
The photochemical behavior of a series of trans-[Ru(NH3) 4L(NO)]3+ complexes, where L=nitrogen bound imidazole, L-histidine, 4-picoline, pyridine, nicotinamide, pyrazine, 4-acetylpyridine, or triethylphosphite is reported. In addition to ligand localized absorption bands (π→NO) charge transfer (MLCT) transitions. Irradiation of aqueous solutions of these complexes with near-UV light (300-370 nm) labilizes NO, i.e.,trans-[Ru(NH3)4L(NO)] 3+→hν[Ru(NH3)4L(H2O)] 3++NOQuantum yields for [Ru(NH3)4L(H 2O)]3+ formation (φRu(III)) are sensitive to the natures of L, λirr and pH. The lowest quantum yields (λirr=310 nm) were found for L = imidazole (0.03) and L-histidine (0.04), while much higher values were found for L=P(OEt) 3 (0.30). Irradiation at longer wavelengths does not induce photochemical reactivity. These results are interpreted in terms of the expected reactivities of dπ→NO MLCT state in these systems.
