77761-09-2Relevant academic research and scientific papers
Ruthenium tetraammines as a model of nitric oxide donor compounds
Toledo, Jose Carlos,Silva, Hildo A. S.,Scarpellini, Marciela,Mori, Vania,Camargo, Ademir J.,Bertotti, Mauro,Franco, Douglas W.
, p. 1879 - 1885 (2004)
The nitric oxide liberation from trans-[Ru(NH3) 4(L)(NO)]3+ (where L = py, 4-pic, isn, nic, L-His, 4-Clpy, imN) after one-electron-chemical or electrochemical reduction was investigated through spectroscopic and electrochemical techniques, reaction-product analysis and quantum-mechanic calculations. These complexes can be formally viewed as a RuII(NO+) species and the reduction site is located on the NO ligand. The E° for the trans-[RuII(NH3) 4(L)(NO+)]3+/trans-[RuII(NH 3)4(L)(NO)]2+ redox process ranges from 0.072 V vs. NHE (nic) to -0.118 V vs. NHE (imN). The specific rate constants for NO dissociation from trans-[RuII(NH3)4(L)(NO)] 2+, evaluated through double-step chronoamperometry, range from 0.025 s-1 (nic) to 0.160 s-1 (ImN) at 25 °C. The [Ru IINO+/ RuIINO°] redox potential and the specific rate constant (k-NO), key steps for designing nitrosyl complexes as NO-donor drug prototypes, proved to be controlled by a judicious choice of the ligand (L) trans to NO. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
