77765-24-3

Upstream product

• 26204-18-2 <α,α,α-2H3>p-xylene 
• 865-50-9 iodomethane-d3 
• 1122-91-4 4-bromo-benzaldehyde 
• 78585-67-8 4-methyl-d3-benzyl alcohol 
• 19215-16-8 p-trideuteromethylbenzoic acid 

Downstream Products

• 925211-40-1 (3R,4S)-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one 
• 925211-41-2 C₁₇H₁₄⁽²⁾H₃NO₃ 
• 925211-42-3 (3R,4S)-1-(p-methoxyphenyl)-3-triisopropylsiloxy-4-(p-trideuteriomethylphenyl)azetidin-2-one 
• 925211-43-4 C₁₉H₂₈⁽²⁾H₃NO₂Si 
• 925211-44-5 (3R,4S)-1-benzoyl-3-triisopropylsilyloxy-4-(p-trideuteriomethylphenyl)azetidin-2-one 
• 925211-47-8 2'-O-(triisopropyl)-3'-(p-trideuteromethylphenyl)-7-O-triethylsilyl-2-debenzoyl-2-(p-fluorobenzoyl)-paclitaxel 

Relevant academic research and scientific papers

Rotational-echo double-resonance NMR distance measurements for the tubulin-bound paclitaxel conformation

The important anticancer drug Taxol (paclitaxel, PTX) owes its unique activity to its ability to bind to tubulin in a stoichiometric ratio and promote its assembly into microtubules. The conformation of the microtubule-bound drug has been the focus of num

Mechanistic duality of the side-chain substitution in electrophilic aromatic nitration. Unexpected large difference in deuterium isotope effect k(H)/k(D) between the side-chain nitration and nitrooxylation of deuterated p-xylenes

A large difference in deuterium kinetic isotope effect observed between the side-chain nitration and nitrooxylation of deuterated p-xylenes, 1,4- (CH3)(CD3)C6H4 and 1,4-(CD3)2C6D4, suggests the operation of different mechanisms for these two types of side-chain substitution.

Rearrangements of the Isomeric Tolylmethylenes

We present evidence for a mechanism in which the isomeric tolylmethylenes interconvert via methylcycloheptatetraene intermediates.Photolysis (>470 nm) of diazo compounds 1-4, matrix isolated in argon at 10 K, generates triplet tolylmethylenes 8-11.Photoly

Kinetics and Mechanism of Acid-Catalyzed Oxidation of Substituted Toluenes by Pyridinium Fluorochromate

The kinetics of oxidation of substituted toluenes by pyridinium fluorochromate(VI) (PFC), C5H5NCrO3F-, in aqueous acetic acid, in the presence of perchloric acid, have been studied.The main products are the corresponding aldehydes.While each of the oxidation is first order with respect to the oxidant, the rate is almost independent of the substrate concentration.The reactions depend on the first power of the concentration of acid.A kinetic isotope effect, kH/kD=5.4 at 30 deg C, was observed.Electron-releasing groups were found to moderately facilitate the reaction, whereas the electron-withdrawing groups were found to have a retardation effect.Correlation with ? value yielded a ρ value of -2.0.The reaction does not induce polymerization of acrylonitrile.The effects of temperature and solvent compositions were studied and activation parameters evaluated.These and related data suggest that the initial reaction involves hydrogen abstraction forming an intermediate which subsequently produces the corresponding aldehyde.