77766-21-3

Basic information

• Product Name: (erythro)-1-methyl-2-hydroxyphenethyl-naphthalene-2,3-dicarboxylic imide
• Synonyms: (erythro)-1-methyl-2-hydroxyphenethyl-naphthalene-2,3-dicarboxylic imide
• CAS NO: 77766-21-3
• Molecular Weight: 331.371
• Mol File: 77766-21-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (erythro)-1-methyl-2-hydroxyphenethyl-naphthalene-2,3-dicarboxylic imide(CAS DataBase Reference)
• NIST Chemistry Reference: (erythro)-1-methyl-2-hydroxyphenethyl-naphthalene-2,3-dicarboxylic imide(77766-21-3)
• EPA Substance Registry System: (erythro)-1-methyl-2-hydroxyphenethyl-naphthalene-2,3-dicarboxylic imide(77766-21-3)

Safety Data

• Hazardous Substances Data: 77766-21-3(Hazardous Substances Data)

Upstream product

• 2169-87-1 naphthalene-2,3-dicarboxylic acid 
• 716-39-2 2,3-Naphthalenedicarboxylic anhydride 
• 492-39-7 rac-Norephedrine hydrochloride 

Downstream Products

• 77766-47-3 (erythro)-2-(2-diethylaminoethyl)-4-(1-methyl-2-hydroxyphenethylamino)-benzo-1(2H)-phthalazinone 
• 77766-42-8 (erythro)-2-(2-hydroxyethyl)-4-(1-methyl-2-hydroxyphenethylamino)-benzo-1(2H)-phthalazinone 
• 77766-37-1 (erythro)-2-methyl-4-(1-methyl-2-hydroxyphenethylamino)-benzo-1(2H)-phthalazinone 
• 77766-32-6 (erithro)-4-(1-methyl-2-hydroxyphenethylamino)-benzo-1(2H)-phthalazinone 
• 77766-27-9 (erythro)-1-methyl-2-tosyloxyphenethyl-naphthalene-2,3-dicarboxylic imide 

Relevant articles and documents

AMINOPHTHALAZINONE DERIVATIVES, VI; SYNTHESIS OF 4-(HYDROXYALKYLAMINO)-BENZO-1(2H)-PHTHALAZINONES

The methods developed from procedures published earlier make possible the synthesis of various 4-(alkylamino-benzo-1(2H)-phthalazinones.Method A (1-->6, 7) is suitable for the incorporation of 1,2- or 1,3-aminoalcohols.When starting from N-β-tosyloxyalkylnaphthalene-2,3-dicarboxylic imides (2; M: -) and 3-bromo-propylimides (3b), parent compounds 6 and the compounds containing methyl, 2-hydroxyethyl and 2-diethylaminoethyl substituents at the N(2) position (7) are formed in excellent and medium yield, respectively.A greater variety of derivatives can be synthesized by Method B, since coupling of 4-chlorobenzo-1(2H)-phthalazinone (9) with aminoalcohols (9-->6a, 6f, 11, 12) is independent of the relative distance between the amino and hydroxy terminals, and the N-substitution (9-->13, 14) of hydroxy-free primary and secondary amines can also be achieved in ethylene glycol solutions.