77768-02-6

Basic information

• Product Name: 2-Pyrimidinecarbonitrile, 4-methyl- (9CI)
• Synonyms: 2-Pyrimidinecarbonitrile, 4-methyl- (9CI);4-Methylpyrimidine-2-carbonitrile;4-Methyl-2-pyriMidinecarbonitrile;2-Cyano-4-methylpyrimidine
• CAS NO: 77768-02-6
• Molecular Formula: C6H5N3
• Molecular Weight: 119.124
• Product Categories: PYRIMIDINE
• Mol File: 77768-02-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 264.9 °C at 760 mmHg
• Flash Point: 100.9 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 0.00943mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Pyrimidinecarbonitrile, 4-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinecarbonitrile, 4-methyl- (9CI)(77768-02-6)
• EPA Substance Registry System: 2-Pyrimidinecarbonitrile, 4-methyl- (9CI)(77768-02-6)

Safety Data

• RIDADR: UN3439
• Hazardous Substances Data: 77768-02-6(Hazardous Substances Data)

Usage

General Description

2-Pyrimidinecarbonitrile, 4-methyl- (9CI) is a chemical compound with the molecular formula C6H5N3. It is a derivative of pyrimidine, which is a heterocyclic aromatic compound. This chemical is commonly used in organic synthesis and as a building block for the preparation of various pharmaceuticals and agrochemicals. It has a wide range of applications and is known for its ability to incorporate into the structure of various organic compounds. 2-Pyrimidinecarbonitrile, 4-methyl- (9CI) is considered to be an important intermediate in the synthesis of various biologically active compounds.

InChI:InChI=1/C6H5N3/c1-5-2-3-8-6(4-7)9-5/h2-3H,1H3

Upstream product

• 13036-57-2 2-chloro-4-methylpyrimidine 
• 33342-83-5 6-methylpyrimidine 1-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 557-21-1 zinc(II) cyanide 
• 773837-37-9 sodium cyanide 
• 557-21-1 dicyanozinc 
• 13435-20-6 tetraethylammoniumcyanide 
• 77767-93-2 Trimethyl-2-(4-methylpyrimidinyl)ammoniumchlorid 
• 17758-54-2 4-methyl-pyrimidine 1-oxide 

Downstream Products

• 933682-85-0 (4-methylpyrimidin-2-yl)methanamine 
• 933738-87-5 4-methyl-pyrimidine-2-carboxylic acid 

Relevant articles and documents

NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS

The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6 R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.

1-(Aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof

Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.