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77768-09-3

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77768-09-3 Usage

General Description

2-Chloro-3-ethoxy-quinoxaline is a chemical compound with the molecular formula C10H9ClN2O. It is a quinoxaline derivative, which is a heterocyclic compound containing a benzene ring fused to a pyrazine ring. 2-Chloro-3-ethoxy-quinoxaline has potential applications in the pharmaceutical industry as a building block for the synthesis of various bioactive compounds. Its chemical structure and properties make it suitable for use in drug development and medicinal chemistry research. The compound is known for its ability to selectively modulate certain biological targets, making it a valuable tool in drug discovery and development efforts. Additionally, 2-Chloro-3-ethoxy-quinoxaline is also used as a research reagent in the study of organic and medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 77768-09-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,7,6 and 8 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 77768-09:
(7*7)+(6*7)+(5*7)+(4*6)+(3*8)+(2*0)+(1*9)=183
183 % 10 = 3
So 77768-09-3 is a valid CAS Registry Number.

77768-09-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloro-3-ethoxyquinoxaline

1.2 Other means of identification

Product number -
Other names 2-Chlor-3-ethoxy-chinoxalin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77768-09-3 SDS

77768-09-3Downstream Products

77768-09-3Relevant articles and documents

Bioorthogonal Ligation and Cleavage by Reactions of Chloroquinoxalines with ortho-Dithiophenols

Fu, Hua,Li, Hongyun,Li, Youshan,Lou, Zhenbang,Yang, Haijun,Zhao, Yufen

, p. 3671 - 3677 (2020/02/04)

A bioorthogonal ligation and cleavage method via reactions of chloroquinoxalines (CQ) and ortho-dithiophenols (DT) is presented. Double nucleophilic substitutions of ortho-dithiophenols to chloroquinoxalines provide conjugates containing tetracyclic benzo[5,6][1,4]dithiino[2,3-b]quinoxaline with strong built-in fluorescence together with release of the other functional molecules. Three cleavable linkers were designed and successfully used in release of the molecules containing biotin from the protein conjugates. The CQ-DT bioorthogonal reactions can be applied for the bioorthogonal ligations, bioorthogonal cleavages, and trans-tagging of proteins, and show advantages of readily accessible unnatural orthogonal groups, appealing reaction kinetics (k2≈1.3 m?1 s?1), excellent biocompatibility of orthogonal groups, and high stability of conjugates. This complements previous bioorthogonal reactions and is a new route for protein-fishing applications and in-gel fluorescence analysis.

Novel multi-component synthesis of 1,4-disubstituted pyrrolo[1,2-a]quinoxalines through palladium-catalyzed coupling reaction/hetero-annulation in water

Keivanloo, Ali,Kazemi, Shaghayegh Sadat,Nasr-Isfahani, Hossein,Bamoniri, Abdolhamid

supporting information, p. 6536 - 6542 (2016/09/23)

1,4-Disubstituted pyrrolo[1,2-a]quinoxalines were prepared through the one-pot multi-component reactions of 3-substituted-2-chloroquinoxalines, propargyl alcohol, and secondary amines, catalyzed by Pd/Cu, in the presence of K2CO3and sodium dodecyl sulfate (SDS) in water. This process provided a facile, eco-friendly, and highly efficient method for the synthesis of new pyrrolo[1,2-a]quinoxalines in water with good yields.

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