77771-04-1

Basic information

• Product Name: 2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane
• Synonyms: 2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane
• CAS NO: 77771-04-1
• Molecular Formula: C₉H₈BrFO₂
• Molecular Weight: 247.06
• Mol File: 77771-04-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane(77771-04-1)
• EPA Substance Registry System: 2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane(77771-04-1)

Safety Data

• Hazardous Substances Data: 77771-04-1(Hazardous Substances Data)

Usage

General Description

2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane is a chemical compound that belongs to the class of dioxolane derivatives. It is composed of a dioxolane ring, which consists of two oxygen atoms and three carbon atoms, and a 3-bromo-4-fluorophenyl group attached to the dioxolane ring. 2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane is commonly used in the field of organic synthesis and pharmaceutical research as a building block for the construction of more complex compounds. Its unique structural properties make it a useful intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. Its potential applications in medicinal chemistry and agrochemical research make it an important compound for further exploration and development.

Upstream product

• 7381-30-8 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 107-21-1 ethylene glycol 

Downstream Products

• 107715-12-8 2-(3-benzyl-4-fluorophenyl)-1,3-dioxolane 
• 77771-05-2 4-fluoro-3-phenoxy-benzaldehyde ethyleneacetal 
• 900800-40-0 2-(3-allyl-4-fluoro-phenyl)-[1,3]dioxolane 
• 166408-36-2 α-Cyano-4-fluoro-3-[(methoxyimino)methyl]benzyl alcohol 
• 166408-34-0 2-{4-Fluoro-3-[(methoxyimino)methyl]phenyl}-1,3-dioxolane 
• 166408-33-9 2-{4-Fluoro-3-[(hydroxyimino)methyl]phenyl}-1,3-dioxolane 
• 166408-35-1 4-Fluoro-3-[(methoxyimino)methyl]benzaldehyde 
• 146137-77-1 2-(3-Formyl-4-fluorophenyl)-1,3-dioxolane 

Relevant articles and documents

Ruthenium-catalyzed enantioselective C-H functionalization: A practical access to optically active indoline derivatives

Ru(II)-catalyzed enantioselective C-H activation/hydroarylation has been developed for the first time, allowing for highly enantioselective synthesis of indoline derivatives via catalytic C-H activation. Commercially available Ru(II) arene complexes and chiral α-methylamines were employed as highly enantioselective catalysts. Based on a sterically rigidified chiral transient directing group, multisubstituted indolines were produced in up to 92% yield with 96% ee. Further transformation of the resulting 4-formylindoline enables access to an optically active tricyclic compound that is of potential biological and pharmaceutical interest.

The Pyrethrins and Related Compounds. Part XXXVIII - Optimisation of Insecticidal Activity in 3-[(Alkoxyimino)methyl]-4-fluorobenzyl Esters

Optimisation of activity in 3-[(alkoxyimino)methylbenzyl] esters has been investigated by introducing an α-cyano group and a fluorine atom in position 4 of the benzylic moiety in conjunction with varying the length and nature of the side chain. Of the five side-chain variations investigated, the 3-methoxyiminomethyl was more effective than others. Introduction of fluorine in position 4 of the benzylic moiety generally increased activity, particularly against mustard beetles, as in previous instances. Surprisingly, the effect on insecticidal activity of introducing an α-CN group ranged from positive to negative depending upon the nature of the alkoxyimino substituent, an effect not observed previously. The most effective esters were derived from α-cyano-4-fluoro-3-[(methoxyimino)methyl]benzyl alcohol, which was synthesised from 2-{4-fluoro-3-[(hydroxyimino)methyl]phenyl}-1,3-dioxolane.

Fluorobenzyl esters

A compound of formula: STR1 wherein R is selected from hydrogen, cyano, methyl, and ethynyl, and X represents the residue of any carboxylic acid of formula X-COOH which forms an insecticidally active ester with a 3-phenoxybenzyl alcohol. The compounds are useful as insecticides and acaricides.