77772-62-4Relevant academic research and scientific papers
Synthesis of Azocanes from Piperidines via an Azetidinium Intermediate
Leverenz, Malte,Masson, Guillaume,Pardo, Domingo Gomez,Cossy, Janine
supporting information, p. 16325 - 16328 (2021/10/25)
α-Trifluoromethyl azocanes are accessible from 2-(trifluoropropan-2-ol) piperidines by metal-free ring-expansion involving a bicyclic azetidinium intermediate. The opening of the azetidinium intermediate was achieved by various nucleophiles (amines, alcoholates, carboxylates, phosphonates, halides and pseudo-halides) with an excellent regio- diastereo- and enantioselectivity and in good yields. The relative configuration of the piperidines and azocanes were assigned and the deprotected azocanes offer opportunities for further derivatization.
Stereodivergent Asymmetric Synthesis of α,β-Disubstituted β-Aminoalkylboronic Acid Derivatives via Group-Selective Protodeboronation Enabling Access to the Elusive Anti Isomer
Li, Xiangyu,Hall, Dennis G.
supporting information, p. 9063 - 9069 (2020/12/23)
Chiral β-aminoalkylboronates generate growing interest as versatile synthetic building blocks to access β-aminoalcohols and other useful compounds, and also as bioisosteres of β-amino acids in drug discovery. In this study, the lack of methodology to acce
Phosphodiester alkylation with a quinone methide
Zhou, Qibing,Turnbull, Kenneth D.
, p. 2847 - 2851 (2007/10/03)
Despite the wide array of studies involving DNA alkylation and cleavage with quinone methide generating compounds, there have been no reports on the alkylation of phosphodiesters with quinone methides. We have investigated the reaction of dialkyl phosphat
Prodrugs of paclitaxel derivatives
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, (2008/06/13)
The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
