77778-22-4Relevant academic research and scientific papers
Antitumor studies. Part 5: Synthesis, antitumor activity, and molecular docking study of 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins
Shrestha, Ajaya R.,Ali, Hamed I.,Ashida, Noriyuki,Nagamatsu, Tomohisa
body text, p. 9161 - 9170 (2009/04/11)
Various novel 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins derivatives have been synthesized by direct coupling of 5-deazaflavins and N-alkyl or aryl amines. The antitumor activities against human tumor cell lines CCRF-HSB-2 and KB cells have been investigated in vitro and many compounds showed promising potential antitumor activities with less cytotoxicities. AutoDock molecular docking into PTK (PDB code: 1t46) has been done for lead optimization of these compounds as potential PTK inhibitors. Some of the synthesized 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins at the 5-position exhibited reasonable binding affinities into PTK with the hydrogen bond through their C5-NH moiety.
Antitumor studies. Part 1: Design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents
Ali, Hamed I.,Tomita, Keiichiro,Akaho, Eiichi,Kambara, Hiroto,Miura, Shinji,Hayakawa, Hiroyuki,Ashida, Noriyuki,Kawashima, Yutaka,Yamagishi, Takehiro,Ikeya, Hisao,Yoneda, Fumio,Nagamatsu, Tomohisa
, p. 242 - 256 (2008/02/02)
Novel 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides were prepared as a new class of antitumor agents and showed significant antitumor activities against NCI-H 460, HCT 116, A 431, CCRF-HSB-2, andKB cell lines. In vivo investigation,
