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Upstream product

• 77778-25-7 10-methyl-2-phenylpyrimido[4,5-b]quinolin-4(10H)-one 
• 100-46-9 benzylamine 
• 100-61-8 N-methylaniline 
• 29954-25-4 6-Chloro-2-phenylpyrimidin-4(3H)-one 
• 77778-21-3 6-(N-methylanilino)-2-phenylpyrimidin-4(3H)-one 

Relevant academic research and scientific papers

Antitumor studies. Part 5: Synthesis, antitumor activity, and molecular docking study of 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins

Various novel 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins derivatives have been synthesized by direct coupling of 5-deazaflavins and N-alkyl or aryl amines. The antitumor activities against human tumor cell lines CCRF-HSB-2 and KB cells have been investigated in vitro and many compounds showed promising potential antitumor activities with less cytotoxicities. AutoDock molecular docking into PTK (PDB code: 1t46) has been done for lead optimization of these compounds as potential PTK inhibitors. Some of the synthesized 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins at the 5-position exhibited reasonable binding affinities into PTK with the hydrogen bond through their C5-NH moiety.