777859-79-7Relevant academic research and scientific papers
Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids
Appendino, Giovanni,Bertolino, Andrea,Minassi, Alberto,Annunziata, Rita,Szallasi, Arpad,De Petrocellis, Luciano,Di Marzo, Vincenzo
, p. 3413 - 3421 (2007/10/03)
Phorboid 20-homovanillates modified on ring C to mimic the constitution and conformation of the ultrapotent vanilloid resiniferatoxin (RTX) and on the AB ring system to suppress the tumour-promoting potential of the terpenoid core were prepared. Several unexpected reactions were discovered, and the structure-activity relationships for this class of vanilloid ligands were expanded. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
Synthesis and evaluation of phorboid 20-homovanillates: Discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity
Appendino, Giovanni,Cravotto, Giancarlo,Palmisano, Giovanni,Annunziata, Rita,Szallasi, Arpad
, p. 3123 - 3131 (2007/10/03)
A number of phorboid 20-homovanillates were prepared by condensation of phorbol 12,13-diesters and 12-dehydrophorbol 13-esters with Mem-homovanillic acid followed by removal of the protecting group with SnCl4 in THF. These compounds were evalua
