777863-65-7

Upstream product

• 63996-36-1 2-(4-bromophenyl]pyridine 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 67-68-5 dimethyl sulfoxide 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 109-04-6 2-bromo-pyridine 
• 5467-74-3 4-Bromophenylboronic acid 
• 135205-66-2 N?cyanosuccinimide 

Relevant academic research and scientific papers

Rhodium-Catalyzed Direct C-H Bond Cyanation in Ionic Liquids

A Cp?Rh(III)/IL-based direct C-H bond cyanation system was developed for the first time. The system is a mild, efficient, and recyclable method for the synthesis of aryl nitriles. Many different directing groups can be used in this cyanation, and the reaction tolerates a variety of functional groups.

Copper-mediated C-H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a cyanating agent

A copper-mediated direct C-H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a safe cyanating agent has been successfully developed by using molecular oxygen as the oxidant. The reaction tolerates a variety of functional groups and provides a facile and efficient method for the synthesis of a wide range of (hetero)aryl nitriles.

A Pd(ii)/Mg-La mixed oxide catalyst for cyanation of aryl C-H bonds and tandem Suzuki-cyanation reactions

A palladium(ii)/magnesium-lanthanum mixed oxide (Pd(ii)/Mg-La) catalyst is a reusable catalyst for cyanation of aromatic C-H bonds by using the combination of NH4HCO3 and DMSO as the ''CN'' source. Moderate to good yields of aromatic nitriles were obtained. An excellent regioselectivity was achieved using the present protocol. A tandem process involving Suzuki coupling followed by a cyanation reaction was also developed using the heterogeneous (Pd(ii)/Mg-La) catalyst. This cascade process resulted in the formation of aromatic nitrile from simple 2-halopyridine. The catalyst was recovered by centrifugation and reused for three consecutive cycles with nearly consistent activity and selectivity. This journal is

Cobalt-catalyzed C-H cyanation of (Hetero)arenes and 6-Arylpurines with N -cyanosuccinimide as a new cyanating agent

A cobalt-catalyzed C-H cyanation reaction of arenes has been developed using N-cyanosuccinimide as a new electrophilic cyanating agent. The reaction proceeds with high selectivity to afford monocyanated products with excellent functional group tolerance. Substrate scope was found to be broad enough to include a wide range of heterocycles including 6-arylpurines.

Copper-mediated direct aryl C-H cyanation with azobisisobutyronitrile via a free-radical pathway

An unprecedented protocol for the copper-mediated direct cyanation of aryl C-H by employing 2,2′-azobisisobutyronitrile (AIBN) as a free radical "CN" source is presented. The protocol not only provides a more efficient pathway for the synthesis of aryl nitriles in terms of the yields and the loading amount of copper salts but also, more importantly, represents a novel strategy for aryl C-H cyanation via a CN free-radical mechanism as compared to the CN anion-participating protocols often reported.