777892-68-9

Upstream product

• 14338-32-0 2-chloro-1-methyl-pyridinium iodide 
• 777892-66-7 allyl-(1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl)-amine 
• 777892-62-3 N-allyl-2-nitro-N-(2-oxo-1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl)-benzenesulfonamide 
• 777892-60-1 2-nitro-N-(2-oxo-1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl)-benzenesulfonamide 
• 777892-64-5 2-allylamino-2-(S)-phenyl-1-pyrrolidin-1-yl-ethanone 
• 2935-35-5 (S)-2-phenylglycine 
• 777892-58-7 (2-nitro-benzenesulfonylamino)-1-(S)-phenyl-acetic acid 

Relevant academic research and scientific papers

Azepinone as a conformational constraint in the design of κ-opioid receptor agonists

A new class of κ-opioid receptor agonists is described. The design of these agents was based upon energy minimization and structural overlay studies of the generic azepin-2-one structure 3 with the crystal structure of arylacetamide κ agonist 1, ICI 19944

Lactam derivatives and methods of their use

Lactam derivatives of the general formula 1 are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed.