77790-73-9

Usage

Uses

Used in Pharmaceutical Industry:
(+/-)-5-hydroxymethyl-3-methyl-4,5-dihydroisoxazole is used as a potential pharmaceutical drug due to its potential biological activities. Its unique structure and properties make it a promising candidate for the development of new drugs to treat various diseases and conditions.
Used in Organic Synthesis:
(+/-)-5-hydroxymethyl-3-methyl-4,5-dihydroisoxazole is used as a starting material for the synthesis of other organic compounds. Its versatile structure allows for the creation of a wide range of chemical products, making it valuable in the field of organic chemistry and synthesis.

Upstream product

• 319911-32-5 5-[(4-bromophenoxy)methyl]-3-methyl-4,5-dihydroisoxazole 
• 114120-89-7 3-methyl-5-phenoxymethyl-4,5-dihydroisoxazole 
• 77790-74-0 3-Methyl-5-(tetrahydro-pyran-2-yloxymethyl)-4,5-dihydro-isoxazole 

Relevant academic research and scientific papers

Microbial Synthesis of Novel 4,5-Dihydroisoxazole Derivatives. Ethereal Bond Cleavage

Microbial biotransformation - cleavage of ethereal bond - in 4,5-dihydroisoxazoles was carried out by using selected yeast Rhodotorulla rubra no. 4 and Aspergillus niger mold fungus. The cleavage of ethereal bond in these compounds afforded alcohols or phenols with a 4,5-dihydroisoxazolic group.

A strategic alternative to solid phase synthesis: Preparation of a small isoxazoline library by 'fluorous synthesis'

The preparation of a highly fluorinated silyl group and its use as a 'fluorous label' are described. Allyl and propargyl alcohols are rendered fluorous upon attachment to the fluorous label. Cycloaddition of the fluorous dipolarophiles to nitrile oxides provides the corresponding isoxazol(in)es which are purified by simple liquid-liquid extractions. After detachment of the label and renewed extraction, the organic isoxazol(in)es are obtained. This new fluorous methodology allows the preparation of isoxazol(in)es in high purities without using chromatography.