77791-09-4Relevant academic research and scientific papers
Palladium-Catalyzed Annulation of Arylbenzamides with Diaryliodonium Salts
Pan, Cheng,Wang, Limin,Han, Jianwei
supporting information, p. 268 - 273 (2021/11/09)
By using diaryliodonium salts, a cylization has been accomplished in the synthesis of N-aryl phenanthridinone derivatives via a cascade of ortho-arylation and Csp2-N bond formation in the presence of palladium catalyst. The reaction exhibits a broad compatibility of readily available N-arylnaphthamides. (Figure presented.).
Preparation and biological properties of ring-substituted naphthalene-1-carboxanilides
Gonec, Tomas,Kos, Jiri,Nevin, Eoghan,Govender, Rodney,Pesko, Matus,Tengler, Jan,Kushkevych, Ivan,Stastna, Vendula,Oravec, Michal,Kollar, Peter,O'mahony, Jim,Kralova, Katarina,Coffey, Aidan,Jampilek, Josef
, p. 10386 - 10409 (2014/08/05)
In this study, a series of twenty- Two ring-substituted naphthalene-1- carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized carboxanilides was performed against Mycobacterium avium subsp. paratuberculosis. N-(2-Methoxyphenyl)naphthalene-1-carboxamide, N-(3-methoxyphenyl) naphthalene-1-carboxamide, N-(3-methylphenyl)naphthalene-1- carboxamide, N-(4-methylphenyl)naphthalene-1-carboxamide and N-(3-fluorophenyl)naphthalene-1- carboxamide showed against M. avium subsp. paratuberculosis two-fold higher activity than rifampicin and three-fold higher activity than ciprofloxacin. The most effective antimycobacterial compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. The testing of biological activity of the compounds was completed with the study of photosynthetic electron transport (PET) inhibition in isolated spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity expressed by IC50 value of the most active compound N-[4-(trifluoromethyl)phenyl]naphthalene-1- carboxamide was 59 μmol/L. The structure- Activity relationships are discussed.
