777918-24-8Relevant academic research and scientific papers
REAGENTS FOR THIOL CONJUGATION AND CONJUGATES FORMED THEREFROM
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Paragraph 0089, (2016/02/29)
Reagents for preparing stabilized thioethers for in vivo administration are disclosed, along with said thioethers thus prepared.
Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions
Buller, Fabian,Mannocci, Luca,Zhang, Yixin,Dumelin, Christoph E.,Scheuermann, Joerg,Neri, Dario
supporting information; experimental part, p. 5926 - 5931 (2009/05/31)
DNA-encoded chemical libraries are increasingly being employed for the identification of binding molecules to protein targets of pharmaceutical relevance. Here, we describe the synthesis and characterization of a DNA-encoded chemical library, consisting of 4000 compounds generated by Diels-Alder cycloaddition reactions. The compounds were encoded with unique DNA fragments which were generated through a stepwise assembly process and serve as amplifiable bar codes for the identification and relative quantification of library members.
