Cas 77797-64-9,Benzenesulfonyl chloride, 5-chloro-2-(trifluoromethoxy)-

77797-64-9

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Basic information

Product Name: Benzenesulfonyl chloride, 5-chloro-2-(trifluoromethoxy)-
Synonyms:
CAS NO:77797-64-9
Molecular Formula: C7H3Cl2F3O3S
Molecular Weight: 295.066
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: Benzenesulfonyl chloride, 5-chloro-2-(trifluoromethoxy)-(CAS DataBase Reference)
NIST Chemistry Reference: Benzenesulfonyl chloride, 5-chloro-2-(trifluoromethoxy)-(77797-64-9)
EPA Substance Registry System: Benzenesulfonyl chloride, 5-chloro-2-(trifluoromethoxy)-(77797-64-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 77797-64-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 77797-64-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,7,9 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 77797-64:
(7*7)+(6*7)+(5*7)+(4*9)+(3*7)+(2*6)+(1*4)=199
199 % 10 = 9
So 77797-64-9 is a valid CAS Registry Number.

77797-64-9Upstream product

77797-64-9Downstream Products

77797-64-9Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND

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Paragraph 0931; 0932, (2019/06/17)

Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY

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Page/Page column 112; 191; 192; 193, (2018/07/29)

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I) or a pharmacologically acceptable salt thereof.

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Pinkerton, Anthony B.,Sergienko, Eduard,Bravo, Yalda,Dahl, Russell,Ma, Chen-Ting,Sun, Qing,Jackson, Michael R.,Cosford, Nicholas D.P.,Millán, José Luis

, p. 31 - 34 (2017/11/27)

Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme crucial for bone matrix mineralization via its ability to hydrolyze extracellular inorganic pyrophosphate (ePPi), a potent mineralization inhibitor, to phosphate (Pi). B

PYRIDO-OXAZINONE DERIVATIVES AS TNAP INHIBITORS

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Page/Page column 159; 160, (2017/02/09)

SULFONAMIDE COMPOUNDS AND USES AS TNAP INHIBITORS

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Paragraph 00720, (2013/09/12)

Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper- mineralization.

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