77799-76-9Relevant academic research and scientific papers
Relationship between anticonvulsant activity and enzyme inhibitory effectiveness of substituted oxadiazoles
Chaudhary,Chaudhary,Parmar,et al.
, p. 105 - 110 (2007/10/02)
Eight 2-(2,6-dimethylphenoxymethyl)-5-arylamino-1,3,4-oxadiazoles were synthesized. All oxadiazoles (100 mg/kg, ip) possessed anticonvulsant activity. This was reflected by 10-60% protection observed against pentylenetetrazol (90 mg/kg, sc)-induced convulsions in mice. All oxadiazoles also inhibited in vitro respiratory activity of rat brain homogenates. The antiproteolytic activity of these oxadiazoles was reflected by their ability to provide protection against in vitro trypsin-induced hydrolysis of bovine serum albumin and this ranged from 21% to 44% at a final concentration of 0.5 mM. All oxadiazoles (2 mM) inhibited in vitro succinate dehydrogenase activity of rat brain homogenates and the degree of inhibition ranged from 25-86%.
