77803-32-8

Usage

Uses

Used in Pharmaceutical Applications:
(8alpha)-12-methoxy-8,19-epoxyibogamine is used as a therapeutic agent for its antidepressant and anti-addictive effects, particularly in the treatment of substance abuse, including opioids and alcohol. It modulates various neurochemical pathways, exerting inhibitory effects on addictive behaviors and depressive symptoms.
Used in Neurodegenerative Disease Treatment:
(8alpha)-12-methoxy-8,19-epoxyibogamine is used as a potential treatment for neurodegenerative diseases and other neurological disorders due to its neuroprotective and anti-inflammatory properties. It may help in mitigating the progression of these diseases and improving the quality of life for patients.
Used in Mental Health Applications:
(8alpha)-12-methoxy-8,19-epoxyibogamine is used as a potential treatment for various mental health disorders, leveraging its psychoactive properties to address underlying neurochemical imbalances and promote overall mental well-being.

Upstream product

• 78946-03-9 6-((Z)-2-[1,3]Dioxolan-2-yl-vinyl)-tetrahydro-pyran-2-one 
• 100-73-2 acrolein dimer 
• 77803-31-7 6-((E)-3-Hydroxy-propenyl)-tetrahydro-pyran-2-one 
• 344400-54-0 tetrahydropyranyl-2-keto-6-β-propenal 
• 1268364-36-8 methyl (E)-8,8-diethoxy-5-oxooct-6-enoate 
• 1268364-37-9 methyl (E)-8,8-diethoxy-5-hydroxyoct-6-enoate 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 77803-29-3 Acetic acid (E)-3-(1,4,6-trioxa-spiro[4.5]dec-7-yl)-allyl ester 
• 76919-63-6 Acetic acid (E)-3-(6-oxo-tetrahydro-pyran-2-yl)-allyl ester 
• 78946-04-0 2-((Z)-2-[1,3]Dioxolan-2-yl-vinyl)-3,4-dihydro-2H-pyran 
• 77803-30-6 (E)-3-(1,4,6-Trioxa-spiro[4.5]dec-7-yl)-prop-2-en-1-ol 

Relevant academic research and scientific papers

An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine

The diverse biological activities of γ-hydroxyalkenal phospholipids and their involvement in disease are the subject of intense study. Phospholipid aldehydes, such as the 4-hydroxy-7-oxohept-5-enoic acid ester of 2-lyso-phosphatidylcholine (HOHA-PC), the 5-hydroxy-8-oxo-6-octenoic acid ester of 2-lyso-PC (HOOA-PC), and the 9-hydroxy-12-oxododec-10-enoic acid ester of 2-lyso-PC (HODA-PC), are generated by oxidative cleavage of polyunsaturated fatty acyl phospholipids. To facilitate investigations of their chemistry and biology, we now report efficient total synthesis of HOOA, HODA, and HOHA phospholipids. Because the target γ-hydroxyalkenals readily decompose through oxidation of the aldehyde group to a carboxylic acid or through cyclization to furans, these synthesis generate the sensitive functional array of the target phospholipids under mild conditions from acetal derivatives that are suitable for long-term storage.

The iron-mediated intramolecular addition of carboxylates to conjugated dienes

Treatment of carboxylic acid functionalized (η4-diene)Fe(CO)3 complexes with 3.0 equiv. of NOBF4 in the presence of Et3N generates γ- and δ-lactones containing an α,β-unsaturated aldehyde or oxime functionality