77811-46-2

Upstream product

• 76153-06-5 5-bromo-3-methylbenzene-1,2-diamine 
• 95-53-4 o-toluidine 
• 77811-44-0 4-bromo-2-methyl-6-nitroaniline 
• 24106-05-6 4'-bromo-2'-methylacetanilide 
• 120-66-1 N-(2-methylphenyl)acetamide 
• 77811-41-7 6-bromo-2-mercapto-4-methylbenzimidazole 
• 99-73-0 para-bromophenacyl bromide 

Downstream Products

• 77829-40-4 6-Bromo-3-(4-bromo-phenyl)-8-methyl-benzo[4,5]imidazo[2,1-b]thiazole 

Relevant academic research and scientific papers

Heterocyclic Systems Containing Bridgehead Nitrogen Atom : Part XXXVIII- Reaction of 6-Bromo-2-mercapto-4-methylbenzimidazole with Chloroacetic Acid, α-Halogenoketones and 1,2-Dibromoethane

6-Bromo-8-methylthiazolobenzimidazol-3(2H)-one (IV), 3-substituted-6-bromo-8-methylthiazolobenzimidazoles (VII) and 2,3-dihydro-6-bromo-8-methylthiazolobenzimidazole (VIII) have been synthesized starting from 6-bromo-2-mercapto-4-methylbenzimidazole (II), prepared by the treatment of 5-bromo-3-methyl-1,2-diaminobenzene (I) with carbon disulphide.II on condensation with chloroacetic acid gives 6-bromo-4-methyl-2-benzimidazothiolacetic acid (III) which on cyclization with acetic anhydride furnishes IV and not the other isomer (V).Condensation of II with α-halogenoketones followed by PPA cyclization of the intermediate ketones (VI) yields 3-aryl-6-bromo-8-methylthiazolobenzimidazoles (VII).A similar reaction of II with 1,2-dibromoethane gives VIII.