77817-08-4Relevant academic research and scientific papers
Direct Conversion of Carboxylic Acids to Alkyl Ketones
Amani, Javad,Molander, Gary A.
supporting information, p. 3612 - 3615 (2017/07/15)
An efficient and mild method for acyl-Csp3 bond formation based on the direct conversion of carboxylic acids has been established. This protocol is enabled by the synergistic, Ir-photoredox/nickel catalytic cross-coupling of in situ activated c
Synergistic Visible-Light Photoredox/Nickel-Catalyzed Synthesis of Aliphatic Ketones via N-C Cleavage of Imides
Amani, Javad,Alam, Rauful,Badir, Shorouk,Molander, Gary A.
, p. 2426 - 2429 (2017/05/12)
An electrophilic, imide-based, visible-light-promoted photoredox/Ni-catalyzed cross-coupling reaction for the synthesis of aliphatic ketones has been developed. This protocol proceeds through N-C(O) bond activation, made possible through the lower activation energy for metal insertion into this bond due to delocalization of the lone pair of electrons on the nitrogen by electron-withdrawing groups. The operationally simple and mild cross-coupling reaction is performed at ambient temperature and exhibits tolerance for a variety of functional groups.
Synergistic Photoredox/Nickel Coupling of Acyl Chlorides with Secondary Alkyltrifluoroborates: Dialkyl Ketone Synthesis
Amani, Javad,Molander, Gary A.
, p. 1856 - 1863 (2017/02/10)
Visible light photoredox/nickel dual catalysis has been employed in the cross-coupling of acyl chlorides with potassium alkyltrifluoroborates. This protocol, based on single-electron-mediated alkyl transfer, circumvents the restriction of using reactive alkylmetallic nucleophiles in transition-metal-catalyzed acylation and achieves a mild and efficient method for the synthesis of unsymmetrical alkyl ketones. In this approach, a variety of acyl chlorides have been successfully coupled with structurally diverse potassium alkyltrifluoroborates, generating the corresponding ketones with good yields.
Synthesis of 1-adamantyl and 1-adamantylmethyl alkyl ketones
Grava, I. Ya.,Polis, Ya. Yu.,Lidak, M. Yu.,Liepin'sh, E. E.,Shatts, V. D.,et al.
, p. 679 - 686 (2007/10/02)
The reaction of 1-adamantanecarboxylic and 1-adamantylacetic acids with Grignard reagents in the presence of cuprous chloride or iodide gave the corresponding ketones.
EFFECT OF STRUCTURE ON THE REACTIVITY OF KETONES OF THE ADAMANTANE SERIES IN OXIMATION REACTIONS
Ivanova, L. P.,Polis, Ya. Yu.,Grava, I. Ya.,Raguel', B. P.,Cherkasova, V. A.,et al.
, p. 272 - 276 (2007/10/02)
Some ketones of the adamantane series were synthesized.Their reactivity in the oximation reaction was studied quantitatively.
