77819-76-2

Upstream product

• 15058-64-7 6-α-hydroxypenicillanic acid 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 77819-77-3 6-alpha-trifluoromethylsulfonyloxypenicillanic acid 4-nitrobenzyl ester 
• 87996-70-1 p-nitrobenzyl (6E)-6-acetonylidenepenicillanate (R)-S-oxide 
• 87996-71-2 p-nitrobenzyl (6E)-6-acetonylidenepenicillanate (S)-S-oxide 
• 87996-61-0 p-nitrobenzyl (6E)-6-acetonylidenepenicillanate 
• 73707-61-6 p-nitrobenzyl 6-ketopenicillanate 

Relevant academic research and scientific papers

Beta-lactamase inhibiting 6-beta-sulfonyloxypenicillanic acid derivatives

6-Beta-sulfonyloxypenicillanic acid derivatives are novel beta-lactamase inhibitors, useful in combination with standard beta-lactam antibiotics against bacterial strains otherwise resistant to said beta-lactam antibiotics by dint of their production of b

6-Perhaloalkylsulfonyloxy-penicillanic acids and derivatives thereof

6-Alpha and 6-beta-substituted penicillanic acid derivatives of the formula: STR1 wherein R is H or a conventional penicillin carboxy protecting group or an ester forming residue readily hydrolyzable in vivo and R1 is a perhaloalkyl group of from 1 to 4 carbon atoms wherein the halogen atoms are fluoro or chloro, undergo SN2 nucleophilic displacement with halide or azide ions with inversion of configuration at C-6 to yield the corresponding 6-beta or 6-alpha-halo- or azido-substituted product.