7782-51-6

Basic information

• Product Name: (2R)-2-acetamido-3-phenyl-propionic acid
• Synonyms: (2R)-2-acetamido-3-phenylpropanoic acid;(2R)-2-acetamido-3-phenyl-propanoic acid;(2R)-2-acetamido-3-phenyl-propionic acid
• CAS NO: 7782-51-6
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.22582
• Mol File: 7782-51-6.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R)-2-acetamido-3-phenyl-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-acetamido-3-phenyl-propionic acid(7782-51-6)
• EPA Substance Registry System: (2R)-2-acetamido-3-phenyl-propionic acid(7782-51-6)

Safety Data

• Hazardous Substances Data: 7782-51-6(Hazardous Substances Data)

Usage

Description

(2R)-2-acetamido-3-phenyl-propionic acid, also known as flurbiprofen, is a non-steroidal anti-inflammatory drug (NSAID) that possesses analgesic and anti-inflammatory properties. It is a member of the propionic acid class of NSAIDs and is primarily used for the treatment of pain, inflammation, and swelling related to conditions such as arthritis and menstrual cramps. The mechanism of action involves the inhibition of prostaglandin production, which are molecules that play a role in pain and inflammation within the body.

Uses

Used in Pharmaceutical Industry:
(2R)-2-acetamido-3-phenyl-propionic acid is used as an analgesic and anti-inflammatory agent for the treatment of pain and inflammation associated with various conditions such as arthritis and menstrual cramps. It is effective in reducing swelling and providing relief from discomfort caused by these conditions.
Used in Pain Management:
(2R)-2-acetamido-3-phenyl-propionic acid is used as a pain management tool for acute pain conditions. It is available in various forms, including tablets, capsules, and topical gels, allowing for flexible administration and targeted relief.
However, it is important to note that flurbiprofen, like other NSAIDs, may cause side effects such as stomach irritation, ulcers, and kidney problems. Therefore, it should be used with caution, particularly in individuals with a history of these conditions or other risk factors.

Upstream product

• 14009-95-1 p-nitrophenyl N-acetyl-D-phenylalaninate 
• 2901-75-9 (R,S)-N-acetyl phenylalanine 
• 55065-02-6 N-acetamido cinnamic acid 
• 55065-02-6 2-(N-acetylamino)cinnamic acid 
• 52386-78-4 N-acetyl dehydrophenylalanine methyl ester 

Downstream Products

• 3618-96-0 Methyl ester of (+)-N-acetylphenylalanine 
• 16225-10-8 2-Acetylamino-3-phenyl-propionyl chloride 

Relevant articles and documents

RHODIUM CATALYST AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE COMPOUND USING THE SAME

PROBLEM TO BE SOLVED: To provide a new rhodium complex stable in the air, easy in handling and using an inexpensive optically active H-phosphinate HP(O)R(OR') as a ligand, and a method for asymmetrically hydrogenating olefins efficiently using the same. SOLUTION: The rhodium complex compound has a structure represented by the following general formula (I). (Where in the formula (I), R1 and R2 are carbon substituents which may be the same or different, and two olefins coordinated in Rh may combine with each other as shown by a dotted line to form a ring structure.) COPYRIGHT: (C)2015,JPOandINPIT

Asymmetric hydrogenation of C=C double bonds using Rh-complex under homogeneous, heterogeneous and continuous mode conditions

A green process for enantioselective hydrogenation of dehydroamino acid derivatives and dimethyl itaconate with a rhodium catalyst modified by a new phosphine-phosphoramidite has been developed providing 97.7-99.8% enantioselectivity in green solvents such as ethylene carbonate and propylene carbonate. The l-DOPA precursor was obtained by simple filtration in 71% yield with 99.5% ee. Dimethyl itaconate was hydrogenated under solvent-free condition at 50 °C with 98.7% ee. The new rhodium complex was heterogenized on a mesoporous Al2O3 support using phosphotungstic acid (PTA) as an anchoring agent and tested in heterogeneous batch and flow reaction modes. The supported catalyst was reused eight times in the batch mode with over 97% ee and used over 12 hours in the flow reaction mode with an average of 97% ee in the asymmetric hydrogenation reaction of (Z)-α-acetamidocinnamic acid methyl ester.

NEW ORTHO-FUNCTIONALIZED P-CHIRAL ARYLPHOSPHINES AND DERIVATIVES: THEIR PREPARATION AND USE IN ASYMMETRIC CATALYSIS

The invention relates to novel organo phosphorus P-chiral optically active compounds of formula (I) having a hydroxyl, mercapto, amino, carboxyl, sulfonyl group on aryl near a phosphorus atom, to the preparation and the use thereof in then asymmetrical catalysis of unsaturated compounds. Novel acylphosphine optically pure ligands embodied in the form of transition metal complexes exhibit an increased activity and enantloselectivity, in particular in asymmetrical hydrogenation, in comparison with the same type Uganda such as DiPAMP.