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7782-89-0

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7782-89-0 Usage

Preparation

Different sources of media describe the Preparation of 7782-89-0 differently. You can refer to the following data:
1. Lithium amide is obtained by dissolution of lithium metal in liquid ammonia. The reaction is slow, but may be catalyzed by cobalt nitrate: 2Li + 2NH3 → 2LiNH2 + H2 It also is obtained by passing gaseous ammonia over lithium hydride: LiH + NH3 → LiNH2 + H2
2. Lithium amide, LiNH2 , may be considered the ammonia analogue of lithium hydroxide in the water system. Lithium amide may be prepared from lithium hydride or lithium metal and ammonia. Industrial preparations use lithium hydride as a starting material. The reaction of lithium metal in a stream of ammonia gas at about 400°C may be used successfully as a preparative method. Lithium may also be reacted with liquid ammonia in the presence of an iron compound as a catalyst. Since amide ion is the strongest base which can exist in ammonia, lithium amide is a very strong base. The compound has a low solubility in liquid ammonia. Lithium amide is hydrolyzed by water to yield lithium hydroxide and ammonia. It is readily oxidized. For example, the substance may be oxidized with dinitrogen oxide to yield lithium azide. Amides of the alkali metals in general must be guarded against air oxidation to prevent the formation of potentially explosive substances.

Reactions

Lithium amide decomposes to imide when heated above 400°C: 2LiNH2 → Li2NH + NH3 It is used in several organic syntheses. Some of these synthetic reactions are based on the mechanism that the terminal alkynes react with the stronger base, the anion, forming the weaker conjugate base: It converts vic dibromide to bromoalkene and then alkyne: Ketones can be converted into alkynes:

Chemical Properties

white to grey fine powder

Physical properties

Colorless needles; tetragonal structure; density 1.178 g/cm3 at 17.5°C; melts around 375°C; starts to decompose at 320°C; decomposes at 400°C; soluble in cold water; decomposes in hot water; slightly soluble in ethanol and liquid ammonia; insoluble in benzene and ether.

Uses

Different sources of media describe the Uses of 7782-89-0 differently. You can refer to the following data:
1. Lithium amide is used in the preparation of active pharmaceutical ingredients and antioxidants. It acts as a catalyst for polymers, as nucleophiles and as strong bases. It serves as a reagent in the synthesis of antiinflamatory and preoresolving protectin D1, chemotype dipeptidyl peptidase IV inhibitors and sterically congested triarylamines. It finds application in dyes displaying large stokes shifts. In addition to this, it is used as a reagent for cross-coupling of aryl chlorides and amine.
2. Reagent for synthesis of: Antiinflamatory and preoresolving protectin D11 Chemotype dipeptidyl peptidase IV inhibitors2 Sterically congested triarylamines3 Dyes displaying large Stokes shifts4 GM1 ganglioside derivatives5Reagent for cross-coupling of aryl chlorides and amines6
3. In Claisen condensations, alkylation of nitriles and ketones, synthesis of ethynyl Compounds, acetylenic carbinols.

General Description

White crystalline powder with an odor of ammonia. Denser than water.

Reactivity Profile

Powdered Lithium amide is highly reactive. A strong base. Reacts to release toxic ammonia gas with water. Forms explosive peroxide on storage.

Safety Profile

A powerful irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat or flame. Ammonia is liberated and lithmm hydroxide is formed when this compound is exposed to moisture. Reacts violently with water or steam to produce toxic and flammable vapors. Vigorous reaction with oxilzing materials. Exothermic reaction with acid or acid fumes. When heated to decomposition it emits very toxic fumes of LiO, NH3, and NO,. Used in synthesis of drugs, vitamins, steroids, and other organics. See also LITHIUM COMPOUNDS, AMIDES, AMMONIA, and LITHIUM HYDROXIDE.

Purification Methods

Purify it by heating at 400o while NH3 is passed over it in the upper of two crucibles (the upper crucible is perforated). The LiNH2 will drip into the lower crucible through the holes in the upper crucible. The product is cooled in a stream of NH3. Protect it from air and moisture, store it under N2 in a clear glass bottle sealed with paraffin. Store it in small quantities so that all the material is used once the bottle is opened. If the colour of the amide is yellow, it should be destroyed as it is likely to have oxidised and to EXPLODE. On heating above 450o it is decomposed to Li2NH, which is stable up to 750-800o. [Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 463 1963, Greenlee & Henne Inorg Synth II 135 1953.]

Check Digit Verification of cas no

The CAS Registry Mumber 7782-89-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,7,8 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 7782-89:
(6*7)+(5*7)+(4*8)+(3*2)+(2*8)+(1*9)=140
140 % 10 = 0
So 7782-89-0 is a valid CAS Registry Number.
InChI:InChI=1/CH5N.Li/c1-2;/h2H2,1H3;

7782-89-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Detail
  • Alfa Aesar

  • (L16023)  Lithium amide, 95%   

  • 7782-89-0

  • 25g

  • 221.0CNY

  • Detail
  • Alfa Aesar

  • (L16023)  Lithium amide, 95%   

  • 7782-89-0

  • 100g

  • 407.0CNY

  • Detail
  • Alfa Aesar

  • (L16023)  Lithium amide, 95%   

  • 7782-89-0

  • 500g

  • 1336.0CNY

  • Detail
  • Aldrich

  • (213217)  Lithiumamide  powder, 95%

  • 7782-89-0

  • 213217-5G

  • 405.99CNY

  • Detail
  • Aldrich

  • (213217)  Lithiumamide  powder, 95%

  • 7782-89-0

  • 213217-100G

  • 703.17CNY

  • Detail
  • Aldrich

  • (213217)  Lithiumamide  powder, 95%

  • 7782-89-0

  • 213217-500G

  • 2,472.21CNY

  • Detail
  • Aldrich

  • (686050)  Lithiumamide  hydrogen-storage grade

  • 7782-89-0

  • 686050-10G

  • 800.28CNY

  • Detail

7782-89-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Lithium amide

1.2 Other means of identification

Product number -
Other names Aminolithium

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7782-89-0 SDS

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