N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide is a benzamide derivative chemical compound with high potency and selectivity as an inhibitor of protein kinase C (PKC) theta. N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide is instrumental in modulating T cell activation and inflammation, making it a promising candidate for treating autoimmune diseases and preventing transplant rejections. Its unique structural features, including trifluoromethoxy and pyrimidinyl-phenylamino groups, enhance its binding affinity and specificity for PKC theta, which is vital for studying immune response signaling pathways.
778274-97-8
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Basic information
- Product Name: N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide
- Synonyms: N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide;Multi-kinase inhibitor I;MDK74978(Multi-kinase inhibitor)
- CAS NO:778274-97-8
- Molecular Formula: C20H17F3N4O3
- Molecular Weight: 418.3691896
- EINECS: -0
- Product Categories: N/A
- Mol File: 778274-97-8.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide(CAS DataBase Reference)
- NIST Chemistry Reference: N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide(778274-97-8)
- EPA Substance Registry System: N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide(778274-97-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 778274-97-8(Hazardous Substances Data)
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778274-97-8 Usage
Uses
Used in Pharmaceutical Industry:N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide is used as a therapeutic agent for the treatment of autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. Its ability to inhibit PKC theta makes it effective in managing conditions characterized by abnormal T cell activation and inflammation.
Used in Transplant Medicine:
In the field of transplant medicine, N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide is used as an immunosuppressive agent to prevent transplant rejection. Its role in modulating the immune response helps in promoting the acceptance of transplanted organs.
Used in Research and Development:
N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide serves as a valuable research tool in the study of signaling pathways involved in immune responses. Its high binding affinity and specificity for PKC theta make it instrumental in understanding the molecular mechanisms underlying T cell activation and inflammation.
Used in Drug Development:
N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide is utilized in the development of novel therapies for various immunological disorders. Its unique mechanism of action and structural features make it a potential candidate for creating new drugs that can effectively target PKC theta and modulate immune responses.
Check Digit Verification of cas no
The CAS Registry Mumber 778274-97-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,8,2,7 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.Calculate Digit Verification of CAS Registry Number 778274-97:
(8*7)+(7*7)+(6*8)+(5*2)+(4*7)+(3*4)+(2*9)+(1*7)=228
228 % 10 = 8
So 778274-97-8 is a valid CAS Registry Number.
778274-97-8Upstream product
778274-97-8Downstream Products
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N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide
