77828-54-7Relevant academic research and scientific papers
Ready access to functionally embellished cis -hydrindanes and cis -decalins: Protecting group-free total syntheses of (±)-nootkatone and (±)-Noreremophilane
Handore, Kishor L.,Seetharamsingh,Reddy, D. Srinivasa
, p. 8149 - 8154 (2013)
A simple and efficient synthesis of functionalized cis-hydrindanes and cis-decalins was achieved using a sequential Diels-Alder/aldol approach in a highly diastereoselective manner. The scope of this method was tested with a variety of substrates and was successfully applied to the synthesis of two natural products in racemic form. The highlights of the present work provide ready access to 13 new cis-hydrindanes/cis-decalins, a protecting group-free total synthesis of an insect repellent Nootkatone, and the first synthesis of a Noreremophilane using the shortest sequence.
