77832-40-7Relevant academic research and scientific papers
Palladium-Catalyzed Synthesis of Biaryl Ketones via tert -Butyl Isocyanide Insertion
Chen, Zhong,Duan, Huaqing,Jiang, Xiao,Wang, Jinmei,Zhu, Yongming,Yang, Shilin
, p. 1425 - 1430 (2014)
A simple and efficient palladium-catalyzed carbonylative Suzuki coupling via tert-butyl isocyanide insertion has been developed, which demonstrates the utility of isocyanides in intermolecular C-C bond construction. This methodology provides a novel pathway for the synthesis of diaryl ketones in moderate to good yields. The approach is tolerant to a wide range of substrates and applicable to library synthesis. A possible reaction mechanism was proposed based on the experimental results. Georg Thieme Verlag Stuttgart. New York.
