77855-48-2Relevant academic research and scientific papers
Probing enzyme stereospecificity. Inhibition of α-chymotrypsin and subtilisin Carlsberg by chiral amine- and aminoalcohol-derivatives
Occhiato, Ernesto,Jones, J. Bryan
, p. 4199 - 4214 (2007/10/03)
Various enantiomeric amine and aminoalcohol amide and α-ketoamide derivatives have been evaluated as competitive inhibitors of the representative serine proteases α-chymotrypsin (CT) and subtilisin Carlsberg (SC). Each compound studied was an effective competitive inhibitor of both enzymes. However, only for the best inhibitor, N-pyruvoyl-1-(1-naphthyl)ethylamine (K1 27 μM for the S-enantiomer with CT), was noteworthy enantiomeric discrimination manifest, with the S-enantiomer being a significantly more powerful inhibitor of CT and SC than its R-counterpart by factors of 12.6- and 73-fold, respectively. The enzyme-inhibitor interactions responsible for this strong binding and enantiomeric discrimination were revealed by molecular modelling analyses.
Asymmetric Reduction of Chiral Pyruvamide with Sodium Borohydride
Munegumi, Toratane,Harada, Kaoru
, p. 298 - 301 (2007/10/02)
Several amides of pyruvic acid with (S)-amines were reduced with sodium borohydride (NBH) in several alcohols and N--(S)-amines were obtained in excess.When the reductions were carried out in methanol or ethanol in the presence of metallic sa
ASYMMETRIC HYDROGENATION OF CHIRAL PYRUVAMIDES
Harada, Kaoru,Munegumi, Toratane,Nomoto, Shinya
, p. 111 - 114 (2007/10/02)
Asymmetric catalytic hydrogenations of three kinds of chiral pyruvamides were carried out using palladium on charcoal as a catalyst to give lactamides with diastereomeric ratios ranging from 76:24 to 98:2.
