77856-40-7Relevant academic research and scientific papers
Solution structural features of N-acyl homoserine lactones
Tumminakatti, Shama,Khatri, Bhavesh,Krishnamurti, Vinayak,Athavale, Vishikh,Prabhakaran, Erode N.
, p. 5771 - 5775 (2015)
Here we demonstrate that in interbacterial quorum signal moderators, N-acylhomoserine lactones (AHLs), the stabilization of bioactive pharmacophore lactone against lysis is through the e- withdrawing N-acyl motif which reduces lactone carbonyl polarization. This lysis is assisted by weak (-1) contacts between N-acyl O and lactone C′. The interactions that preclude this weak contact, in the free and receptor-bound AHLs, improve lactone halflife and hence are key to the design of the antibacterial AHL analogues.
