778561-25-4Relevant articles and documents
Anhydroazasugars as key intermediates in the stereocontrolled preparation of azasugars and their ethyl thioglycosides
Fuentes, Jose,Sayago, Francisco J.,Illangua, Jose M.,Gasch, Consolacion,Angulo, Manuel,Pradera, M. Angeles
, p. 603 - 615 (2007/10/03)
Bicyclic azasugar thioglycosides, a new type of azasugar and alkaloid derivative, are stereoselectively prepared from easily available glycosylenamines (D-gluco and L-rhamno configurations), via 1,4-anhydroazasugar derivatives. Polyhydroxylated pyrrolidines (nonreducing pyrrolidine azasugars) are also prepared by reduction with sodium cyanoborohydride of the same 1,4-anhydroazasugars. The stereochemical assignments of the new stereogenic centres are based on NMR experiments, including a study of the interproton distances from quantitative treatment of NOE data and molecular modeling.
DERIVATIVES OF 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL AND A PROCESS FOR THEIR PREPARATTON
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, (2008/06/13)
Novel derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and method for their synthesis from 4,5-anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol or its triflate derivative are disclosed. The novel derivatives, 6-fluoro-1,4-imino-1,4,6-trideoxy-D-manni
UNTERSUCHUNGEN ZUR STRUCTUR DES α-D-GLUCOSIDASEINHIBITORS ACARBOSE
Junge, Bodo,Heiker, Fred-R.,Kurz, Juergen,Mueller, Lutz,Schmidt,Delf D.,Wuensche, Christian
, p. 235 - 268 (2007/10/02)
Hydrolysis of the pseudotetrasaccharide acarbose (1), a potent inhibitor of intestinal α-D-glucosidases and effective oral antidiabetic agent, gave D-glucose and a tricyclic compound (1R,2S,3R,4aS,7R,8S,8aS,9aR)-1,2,3,4a,7,8,8a,9a-octahydro-1,2,7,8-tetrah