778574-06-4

Basic information

• Product Name: 6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE
• Synonyms: 6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE;6-Benzyl-2,4-dichloro-5,6...;6-benzyl-2;2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyriMidine;6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidine hydrochloride salt;6-benzyl-2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine;6-Benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine, 99.3%
• CAS NO: 778574-06-4
• Molecular Formula: C₁₄H₁₃Cl₂N₃
• Molecular Weight: 294.18
• EINECS: 1533716-785-6
• Product Categories: CHIRAL CHEMICALS;pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 778574-06-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 423.9 °C at 760 mmHg
• Flash Point: 210.2 °C
• Appearance: /
• Density: 1.362 g/cm³
• Refractive Index: 1.584
• PKA: 4.42±0.20(Predicted)
• CAS DataBase Reference: 6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE(778574-06-4)
• EPA Substance Registry System: 6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE(778574-06-4)

Safety Data

• Hazardous Substances Data: 778574-06-4(Hazardous Substances Data)

Usage

General Description

6-Benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine is a chemical compound with potential biological and pharmaceutical applications. It belongs to the class of tetrahydropyrido[4,3-d]pyrimidine compounds, which have been studied for their anti-inflammatory, analgesic, and antifungal properties. The presence of benzyl and dichloro groups in the molecule indicate potential reactivity and solubility, making it a promising candidate for further research and development in medicinal chemistry. Studies have also shown its potential as an anticancer and antiviral agent, further highlighting its significance in drug discovery and development.

InChI:InChI=1/C7H7Cl2N3/c8-6-4-3-10-2-1-5(4)11-7(9)12-6/h10H,1-3H2

Upstream product

• 135481-57-1 5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione 
• 1454-53-1 ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 
• 793-19-1 bis(2-methoxycarbonylethyl)benzylamine 
• 100-46-9 benzylamine 
• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 

Downstream Products

• 1208901-69-2 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride 
• 1257328-38-3 C₂₀H₁₉ClN₄O₂S 
• 1257328-46-3 C₂₁H₂₁ClN₄O₂S 
• 1257328-43-0 C₂₀H₁₇Cl₃N₄O₂S 
• 1257328-39-4 C₂₀H₁₈Cl₂N₄O₂S 
• 1208124-23-5 C₂₄H₂₁ClN₄O₂S 
• 1257328-44-1 C₂₀H₁₇Cl₃N₄O₂S 
• 1257328-49-6 C₂₁H₂₁ClN₄O₃S 
• 1257328-47-4 C₂₁H₂₁ClN₄O₂S 
• 1257328-40-7 C₂₁H₂₁ClN₄O₂S 
• 1257328-45-2 C₂₄H₂₁ClN₄O₂S 
• 1257328-41-8 C₂₃H₂₅ClN₄O₂S 
• 1257328-51-0 C₂₁H₂₀Cl₂N₄O₂S 
• 1208124-24-6 C₂₀H₁₈Cl₂N₄O₂S 

Relevant articles and documents

SUBSTITUTED PHENYLPROPENYL PYRIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL APPLICATIONS

Disclosed are a substituted phenylpropenylpyridine derivative, a preparation method therefor and the use thereof as a PD-1/PD-L1 inhibitor. In particular, disclosed are a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, a preparation method therefor and the use thereof. The definition of each group in the formula is detailed in the description and claims.

Synthesis and evaluation of novel fused pyrimidine derivatives as GPR119 agonists

A novel series of fused pyrimidine derivatives were designed, synthesized and evaluated as GPR119 agonists. Among them, cyclohexene fused compounds (tetrahydroquinazolines) showed greater GPR119 agonistic activities than did dihydrocyclopentapyrimidine and tetrahydropyridopyrimidine scaffolds. Analogues (16, 19, 26, 28, 42) bearing endo-N-Boc-nortropane amine and fluoro-substituted aniline exhibited better EC50 values (0.27–1.2 μM) though they appeared to be partial agonists.

GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.