77858-04-9

Basic information

• Product Name: (1-Ethyl-propylidene)-((S)-1-methoxymethyl-2-phenyl-ethyl)-amine
• Synonyms: (1-Ethyl-propylidene)-((S)-1-methoxymethyl-2-phenyl-ethyl)-amine
• CAS NO: 77858-04-9
• Molecular Weight: 233.354
• Mol File: 77858-04-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1-Ethyl-propylidene)-((S)-1-methoxymethyl-2-phenyl-ethyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Ethyl-propylidene)-((S)-1-methoxymethyl-2-phenyl-ethyl)-amine(77858-04-9)
• EPA Substance Registry System: (1-Ethyl-propylidene)-((S)-1-methoxymethyl-2-phenyl-ethyl)-amine(77858-04-9)

Safety Data

• Hazardous Substances Data: 77858-04-9(Hazardous Substances Data)

Upstream product

• 64715-80-6 (S)-1-benzyl-2-methoxyethylamine 
• 96-22-0 pentan-3-one 

Downstream Products

• 51532-31-1 (+)-(S)-4-methyl-heptane-3-one 
• 51532-30-0 (S)-(+)-4-methylheptan-3-one 

Relevant articles and documents

An Asymmetric Synthesis of Acyclic and Macrocyclic α-Alkyl Ketones. The Role of (E)- and (Z)-Lithioenamines

Metalation and alkylation of chiral imines derived from C10, C12, and C15 cyclic ketones gave, under kinetic metalation conditions, 2-alkylcycloalkanones of absolute configuration opposite to that formed from thermodynamic metalation.Thus, (S)-(-)-2-methylcyclododecanone is formed kinetically in 60percent ee, whereas (R)-(+)-methylcyclododecanone is reached in 80percent ee under thermodynamic conditions.In a similar fashion, acyclic ketones 20, via their chiral imines 17, are alkylated enantioselectively under both kinetic and thermodynamic modes.The kinetic metalation gives exclusively the (Z)-lithioenamines (19), while reflux of this lithio anion gives only the (E)-lithioenamine (19).Chiral α-substituted ketones are produced in 18-97percent ee.