778591-73-4

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 141525-15-7 ethyl 2-[2-(4-chlorophenyl)-1-ethoxyethylidene]hydrazinecarboxylate 
• 43002-66-0 ethyl 2-(4-chlorophenyl)acetimidate hydrochloride 
• 778591-71-2 ethyl [4-amino-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetate 
• 147440-65-1 4-amino-3-(p-chlorobenzyl)-1H-1,2,4-triazol-5-one 

Downstream Products

• 1000865-82-6 1-[4-amino-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl-4-benzyl semicarbazide 
• 1000865-76-8 1-[4-amino-3-(4-chlorbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl-4-benzyl thiosemicarbazide 
• 1000865-79-1 1-[4-amino-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetyl-4-(3-fluorophenyl)thiosemicarbazide 

Relevant academic research and scientific papers

Design, Synthesis, and Biological Evaluation of Coumarin–Triazole Hybrid Molecules as Potential Antitumor and Pancreatic Lipase Agents

The design, synthesis, and investigation of antitumor and anti-lipase activities of some coumarin–triazole hybrid molecules are reported. The synthesis of these hybrid molecules was performed under microwave irradiation and conventional heating procedures

Microwave-assisted synthesis of some new coumarin derivatives including 1,2,4-triazol-3-one and investigation of their biological activities

By using the microwave technology, a new protocol has been developed for the synthesis of new coumarin derivatives including 1,2,4-triazol-3-one skeleton. This protocol proves to be efficient and environmentally friendly in terms of easy work-up and good yields. All newly synthesized compounds were screened for their antimicrobial activity and lipase inhibition. Most of the compounds were found to be effective on Escherichia coli. N'-{[4-Amino-3-(2-bromobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2H-chromene-3-carbohydrazide and N'-{[4-amino-3-(3,4-dichlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2H-chromene-3-carbohydrazide had a good effect on lipase inhibition.

Synthesis and antimicrobial activities of some new 1-(5-phenylamino-[1,3,4] thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4-phenyl-5-thioxo-[1,2,4] triazol-3-yl)methyl-5-oxo- [1,2,4]triazole derivatives

Acetic acid ethyl esters containing 5-oxo-[1,2,4]triazole ring (2) were synthesized by the condensation of compounds 1a-f with ethyl bromoacetate in basic media. The reaction of compounds 2a-f with hydrazine hydrate led to the formation of acid hydrazides