77868-56-5Relevant academic research and scientific papers
The Prominent Effect of N6-Acyl Groups on the Reactivity of 9-Substituted Adenines: A New Method for the Chemical Modification of Adenines
Maki, Yoshifumi,Kameyama, Keiji,Suzuki, Mikio,Sako, Magoichi,Hirota, Kosaku
, p. 3601 - 3654 (2007/10/02)
The effect of various N6-substituents on the C(8)-hydrogen exchange of 9-substituted adenines has been estimated.The kinetic data clearly demonstrate that the N6-acyl groups significantly accelerate the C(8)-hydrogen exchange.This fa
N7-ALKYLATION AND RING-TRNSFORMATION OF N6-ACYL-9-SUBSTITUTED ADENINES
Maki, Yoshifumi,Suzuki, Mikio,Kameyama, Keiji,Kawai, Masaru,Suzuki, Munehiro,Sako, Magoichi
, p. 895 - 898 (2007/10/02)
An N6-acyl group in 9-substituted adenines shows the prominent substituent effect in the alkylation with alkyl halides; In a sharp contrast to 9-substituted adenines, alkylation of their N6-acyl derivatives occurred at N7-nitrogen rather then N1-nitrogen.The N6-acyl-7-alkyl-9-substituted adeninium halogenides thus prepared were converted into 7-substituted adenine and pteridine derivatives.
