77868-75-8Relevant academic research and scientific papers
A facile conversion of 2-substituted acrylamides to 1,3-disubstituted 3-bromo-2-azetidinones
Torii,Okumoto,Yabuki
, p. 517 - 523 (1993)
N-Substituted 2,3-dibromo-2-alkylacrylamides obtained by the bromination of 2-alkylacrylamides were converted to 1,3-disubstituted 3-bromo-2-azetidinones in excellent yields upon treatment with potassium carbonate in acetone under refluxing.
Convenient Syntheses of Cyclic Carboxamides from α,β,γ,δ and ε-halocarboxamides under Phase Transfer Conditions
Okawara, Tadashi,Matsuda, Takashi,Furukawa, Mitsuru
, p. 1225 - 1233 (2007/10/02)
Piperazine-2,5-diones (2) were prepared by N-alkylation between two molecules of α-halocarboxamides (1) in the presence of a phase transfer catalyst in yields of 64-88percent. β,γ,δ and ε-Lactams (6,9 and 13) were similarly synthesized by intramolecular N-alkylation of the corresponding halocarboxamides (5, 8 and 12) under phase transfer conditions in 53-99percent yields.Keywords--piperazine-2,5-dione; β-lactam; γ, δ, and ε lactams; bis-β-lactam; phase transfer catalyst; intramolecular N-alkylation
