77878-41-2

Upstream product

• 77878-32-1 11-benzyloxy-6,10-dimethyl-2-trimethylsiloxy-undec-1,5-diene 
• 77878-59-2 ethyl 8-(benzyloxy)-3,7-dimethyl-2-octenoate 
• 77878-12-7 8-(benzyloxy)-3,7-dimethyl-2-octenol 
• 77878-55-8 (E)-2-Acetyl-10-benzyloxy-5,9-dimethyl-dec-4-enoic acid ethyl ester 
• 77878-09-2 11-(benzyloxy)-1-bromo-6,10-dimethyl-2-oxoundec-5-ene 
• 77878-07-0 ((E)-8-Chloro-2,6-dimethyl-oct-6-enyloxymethyl)-benzene 
• 90432-92-1 2-(5-Benzyloxy-4-methyl-pentyl)-2-methyl-[1,3]dioxolane 
• 77878-52-5 1(Benzyloxy)-2-methyl-6-oxoheptane 
• 73617-67-1 2-(5-hydroxy-4-methylpentyl)-2-methyl-1,3-dioxolane 
• 38237-34-2 2-Methyl-2-(4-methyl-4-pentenyl)-1,3-dioxolane 
• 15580-05-9 5-(2-methyl-1,3-dioxolan-2-yl)-2-pentanone 
• 77878-39-8 11-benzyloxy-1-bromo-6,10-dimethyl-5,6-epoxy-undecan-2-one 

Downstream Products

• 77878-62-7 (1RS,4RS,5SR)-4-<5-(Benzyloxy)-4-methylpentyl>-1-methoxy-4-methyl-3,8-dioxabicyclo<3.2.1>octane 
• 67441-54-7 (1RS,4SR,5RS)-4-(5-hydroxy-4,8-dimethyl-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo<3.2.1>octane-1-acetic acid 
• 77878-43-4 7-benzyloxy-2-[2-bromomethyl-2-methoxy-tetrahydrofuran-5-yl]-6-methyl-heptan-2-ol 

Relevant academic research and scientific papers

(1RS,4SR,5RS)-4-(5-Hydroxy-4,8-dimethyl-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclooctane-1-acetic Acid from Geraniol

(E)-Geraniol (4) has been converted via 13 steps involving epoxidations, hydrolytic epoxide ring opening, and two ring closures to the key intermediate 3,8-dioxabicyclooctane alcohol 10 having stereochemical integrity at all three centers of asymmetry.Extension of the three-carbon side chain of 10 and attachment of the acetic acid side chain at C-1 in nine steps completed the geraniol-based total synthesis of the zoapatanol related bicyclic acid 3.The total synthesis of 3 from the ketal-ketone 5 has also been described.

Synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid

A method of synthesizing 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo [3.2.1]octane-1-acetic acid. The acid is a derivative of the natural product zoapatanol, one of the active ingredients in the zoapatle plant, and is active as a utero-evacuant agent.