77887-27-5Relevant academic research and scientific papers
Asymmetric Synthesis. Asymmetric Catalytic Hydrogenation Using Chiral Chelating Six-Membered Ring Diphosphines
MacNeil, Patricia A.,Roberts, Nicholas K.,Bosnich, B.
, p. 2273 - 2280 (2007/10/02)
Rhodium(I) catalysts formed by the two chiral chelating six-membered ring diphosphines, 2,4-bis(diphenylphosphino)pentane (skewphos) and 1,3-bis(diphenylphosphino)butane (chairphos), are efficient catalysts for the hydrogenation of amino acid precursors.The two chiral phosphines differ in that skewphos probably adopts a chiral conformation whereas chairphos probably adopts an achiral conformation.This comparison evidences the importance of ring conformations in determining optical yields.The mechanism of asymmetric hydrogenation is discussed, and a number of particular and general conclusions are drawn which may prove useful in predicting optical yields from asymmetric synthesis.
