77891-10-2Relevant academic research and scientific papers
Syntheses with α-Metalated Isocyanides, XLVII. - A Reagent for Nucleophilic 1,3-Diaminopropylation
Hoppe, Inga,Schoellkopf, Ulrich
, p. 103 - 106 (2007/10/02)
1-Tosyltetrahydropyrimidine 3 reacts with butyllithium (or LDA) to give the lithium compound 4 which undergoes ring opening to yield the isocyanide 5.This reacts with a second mole buthyllithium to furnish 1-lithio-3-propyl isocyanid
