77894-51-0

Basic information

• Product Name: cis-4-hydroxy-2,3-bis(4-methoxyphenyl)-3,4-dihydro-1(2H)-isoquinolone
• CAS NO: 77894-51-0
• Molecular Weight: 375.424
• Mol File: 77894-51-0.mol

Chemical Properties

• CAS DataBase Reference: cis-4-hydroxy-2,3-bis(4-methoxyphenyl)-3,4-dihydro-1(2H)-isoquinolone(CAS DataBase Reference)
• NIST Chemistry Reference: cis-4-hydroxy-2,3-bis(4-methoxyphenyl)-3,4-dihydro-1(2H)-isoquinolone(77894-51-0)
• EPA Substance Registry System: cis-4-hydroxy-2,3-bis(4-methoxyphenyl)-3,4-dihydro-1(2H)-isoquinolone(77894-51-0)

Safety Data

• Hazardous Substances Data: 77894-51-0(Hazardous Substances Data)

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 1749-08-2 N-(4-methoxy benzylidene)-4-methoxyaniline 

Downstream Products

• 77894-52-1 Acetic acid (3R,4S)-2,3-bis-(4-methoxy-phenyl)-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester 
• 77894-52-1 Acetic acid (3R,4R)-2,3-bis-(4-methoxy-phenyl)-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester 

Relevant articles and documents

A New Route to Diarylisoquinolones

The lithium salts derived from position 3 of phthalides react with Schiff's bases to form a mixture of cis- and trans-2,3-disubstituted 4-hydroxy-3,4-dihydro-1(2H)-isoquinolones, the former isomer predominating.Acid-catalysed dehydration of the alcohols gives 2,4-disubstituted 1(2H)-isoquinolones, as a result of aryl group migration, whilst the cis-isomers, with methanesulphonyl chloride-pyridine as dehydrating agent, produce the 2,3-disubstituted 1(2H)-isoquinolones.

A ONE-STEP ROUTE TO 4-HYDROXY-2,3-DIARYL-3,4-DIHYDRO-1(2H)-ISOQUINOLONES

A new procedure for the synthesis of 2,3-diaryl-3,4-dihydro-4-hydroxy-1(2H)-isoquinolones is described in which the cis-isomer predominates.Dehydration leads to 2,4-diarylisocarbostyrils.