779-73-7

Usage

Molecular Weight

211.25 g/mol This is the mass of one mole of the compound, calculated from its molecular formula.

Appearance

Pale yellow solid This describes the physical appearance of the compound.

Melting Point

152-156°C This is the temperature range at which the compound changes from a solid to a liquid state.

Solubility

Slightly soluble in water, soluble in organic solvents such as ethanol and methanol This indicates the solubility of the compound in different solvents.

Derivative of Pyrrolidine

The compound is a derivative of pyrrolidine, which is a five-membered cyclic amine.

Contains a Sulfur Group

The compound contains a sulfur group attached to a phenyl ring.

Attached to a Phenyl Ring

The sulfur group is attached to a phenyl ring, which is a six-membered carbon ring.

Fluorine Atom

The compound contains a fluorine atom attached to the phenyl ring.

Use as a Reagent

The compound is commonly used as a reagent in organic synthesis.

Potential Biological and Pharmacological Properties

The compound has been studied for its potential use as a drug intermediate or in medicinal chemistry research.

Toxic or Hazardous Properties

The compound may have toxic or hazardous properties if not used properly in a controlled laboratory setting.

Upstream product

• 371-42-6 4-Fluorothiophenol 
• 128-09-6 N-chloro-succinimide 

Downstream Products

• 351-67-7 benzyl-(4-fluorophenyl)-sulfide 

Relevant academic research and scientific papers

Catalytic Electrophilic Thiocarbocyclization of Allenes

An efficient approach via catalytic electrophilic thiocarbocyclization of allenes to construct indene-based sulfides with excellent regioselectivities is disclosed. The reactions were carried out at low temperatures by selenide catalysis in the presence o

Enantioselective Construction of Axially Chiral Amino Sulfide Vinyl Arenes by Chiral Sulfide-Catalyzed Electrophilic Carbothiolation of Alkynes

The enantioselective construction of axially chiral compounds by electrophilic carbothiolation of alkynes is disclosed for the first time. This enantioselective transformation is enabled by the use of a Ts-protected bifunctional sulfide catalyst and Ms-protected ortho-alkynylaryl amines (Ts=tosyl; Ms=mesyl). Both electrophilic arylthiolating and electrophilic trifluoromethylthiolating reagents are suitable for this reaction. The obtained products of axially chiral vinyl–aryl amino sulfides can be easily converted into biaryl amino sulfides, biaryl amino sulfoxides, biaryl amines, vinyl–aryl amines, and other valuable difunctionalized compounds.

h-BN@Copper(II) nanomaterial catalyzed cross-coupling reactions between sulfoximines and N-(phenylthio)-succinimide under mild condition

A novel and efficient method for the synthesis of N-S substituted sulfoximines has been established with h-BN-supported copper(II) nanomaterial as the catalyst. Catalyzed by this heterogeneous catalyst, the desired products were obtained with wide scope of substrates, good to excellent yields, free ligand and low-toxicity solvent. Moreover, after being reused ten times, there is almost no significant loss of its catalytic activity.

AlCl3-Catalyzed Intermolecular Annulation of Thiol Derivatives and Alkynes by 1,2-Sulfur Migration: Construction of 6-Substituted Benzo[b]thiophenes

A method for the AlCl3-catalyzed intermolecular oxidative annulation of N-(arylthio)phthalimide derivatives with alkynes has been developed. The annulation reaction occurs at room temperature and involves the oxidative cleavage of the S–N bond and 1,2-sulfur migration, which leads to the construction of diverse arrays of π-conjugated 6-substituted 2,3-diarylbenzo[b]thiophene derivatives.

MERCAPTOACYL DERIVATIVES OF SUBSTITUTED PROLINES

New mercaptoacyl derivatives of substituted prolines which have the general formula STR1 are useful as hypotensive agents.