77902-94-4Relevant academic research and scientific papers
Versatile β-Keto Ester and β-Keto Nitrile Synthesis through Sulfide Contraction.
Shiosaki, Kazumi,Fels, Gregor,Rapoport, Henry
, p. 3230 - 3234 (1981)
A versatile and efficient synthesis for various β-keto esters, including those which are α substituted, is described.The α-thio iminium salt prepared from a thioamide and a primary or secondary alkylating agent is subjected to sulfur extrusion upon addition of base and a phosphine thiophile, and the result is an enamino ester which may be hydrolyzed to the desired β-keto ester.The method is also applicable to the preparation of various substituted β-keto nitriles.
