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77909-99-0

(LEU8,D-TRP22,TYR25)-SOMATOSTATIN 28, also known as SOM230, is a synthetic analogue of the naturally occurring peptide hormone somatostatin. It is characterized by modifications at positions 8, 22, and 25 in the amino acid sequence, which include the substitution of leucine at position 8, D-tryptophan at position 22, and tyrosine at position 25. These modifications result in enhanced stability and potency compared to the native somatostatin, making it a valuable tool for studying the pharmacological effects of somatostatin and a potential therapeutic agent for various hormone-related disorders.

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  • 77909-99-0 Structure

  • Basic information

    1. Product Name: (LEU8,D-TRP22,TYR25)-SOMATOSTATIN 28
    2. Synonyms: somatostatin 28 [Leu8, D-Trp22, Tyr25];H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Leu-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-D-Trp-Lys-Thr-Tyr-Thr-Ser-Cys-OH
    3. CAS NO:77909-99-0
    4. Molecular Formula: C138H209N41O40S2
    5. Molecular Weight: 3146.52
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 77909-99-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.54±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: −20°C
    8. Solubility: N/A
    9. CAS DataBase Reference: (LEU8,D-TRP22,TYR25)-SOMATOSTATIN 28(CAS DataBase Reference)
    10. NIST Chemistry Reference: (LEU8,D-TRP22,TYR25)-SOMATOSTATIN 28(77909-99-0)
    11. EPA Substance Registry System: (LEU8,D-TRP22,TYR25)-SOMATOSTATIN 28(77909-99-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 77909-99-0(Hazardous Substances Data)

77909-99-0 Usage

Uses

Used in Pharmaceutical Industry:
(LEU8,D-TRP22,TYR25)-SOMATOSTATIN 28 is used as a therapeutic agent for the treatment of hormone-related disorders, such as acromegaly, neuroendocrine tumors, and other conditions characterized by excessive growth hormone secretion. Its enhanced stability and potency make it a promising candidate for the development of new treatments for these disorders.
Used in Research and Development:
(LEU8,D-TRP22,TYR25)-SOMATOSTATIN 28 is used as a research tool for studying the pharmacological effects of somatostatin and its role in regulating various physiological processes, including the inhibition of growth hormone, insulin, and glucagon release. This knowledge can contribute to the development of new therapeutic strategies for hormone-related disorders and a better understanding of the underlying mechanisms involved in these conditions.
Used in Diagnostic Applications:
(LEU8,D-TRP22,TYR25)-SOMATOSTATIN 28 may also be used in diagnostic applications, such as in the development of diagnostic tests for hormone-related disorders or in the imaging of tumors and other abnormalities in the endocrine system. Its high affinity for somatostatin receptors can be exploited to improve the accuracy and sensitivity of diagnostic procedures.

Check Digit Verification of cas no

The CAS Registry Mumber 77909-99-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,9,0 and 9 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 77909-99:
(7*7)+(6*7)+(5*9)+(4*0)+(3*9)+(2*9)+(1*9)=190
190 % 10 = 0
So 77909-99-0 is a valid CAS Registry Number.

77909-99-0Upstream product

77909-99-0Downstream Products

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