77921-76-7Relevant academic research and scientific papers
Chain extension of amino acid skeletons: Preparation of ketomethylene isosteres
Theberge, Cory R.,Zercher, Charles K.
, p. 1521 - 1527 (2007/10/03)
Ketomethylene isosteric replacements for peptide bonds were generated through a zinc carbenoid-mediated chain extension reaction in which a variety of amino acid-derived β-keto esters are converted to γ-keto esters in a single step. The reaction tolerates a variety of protecting groups and amino acid side chains with no epimerization of the amino acid stereocenter.
