77942-46-2

Basic information

• Product Name: 1-methyl-6-phenylethynyl-3,6-dihydropyrimidin-2(1H)-one
• Synonyms: 1-methyl-6-phenylethynyl-3,6-dihydropyrimidin-2(1H)-one
• CAS NO: 77942-46-2
• Molecular Weight: 212.251
• Mol File: 77942-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-methyl-6-phenylethynyl-3,6-dihydropyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-6-phenylethynyl-3,6-dihydropyrimidin-2(1H)-one(77942-46-2)
• EPA Substance Registry System: 1-methyl-6-phenylethynyl-3,6-dihydropyrimidin-2(1H)-one(77942-46-2)

Safety Data

• Hazardous Substances Data: 77942-46-2(Hazardous Substances Data)

Upstream product

• 6738-06-3 phenylethynylmagnesium bromide 
• 3739-81-9 1-methyl-1H-pyrimidin-2-one 

Relevant articles and documents

Reaction of Pyrimidin-2(1H)-ones and -thiones with Organometallic Compounds. Regioselective Preparation of Dihydropyrimidin-2(1H)-ones and -thiones

4,6-Dimethyl-1-phenylpyrimidin-2(1H)-one (1) reacted with methylmagnesium iodide to afford 4,6,6-trimethyl-1-phenyl-3,6-dihydropyrimidin-2(1H)-one (8a) selectively; compound (1) reacted with methyl-lithium to give mainly 4,4,6-trimethyl-1-phenyl-3,4-dihydropyrimidin-2(1H)-one (8b).The reactions of various pyrimidin-2(1H)-ones and -thiones with organometallic compounds, and the influence of bulkiness of alkyl groups upon the product ratio, are also discussed.