77946-35-1Relevant academic research and scientific papers
Synthesis of Double-Bond-Substituted Hemithioindigo Photoswitches
Gerwien, Aaron,Reinhardt, Till,Mayer, Peter,Dube, Henry
, p. 232 - 235 (2018)
A very short, high yielding, and convergent synthesis with broad substrate scope, enabling access to a very diverse range of hemithioindigos with 4-fold substituted double-bonds, is presented. With this method, carbon as well as nitrogen, oxygen, or sulfur based substituents can easily be introduced, delivering a wide array of novel structural motifs. Irradiation studies with visible light demonstrate proficient photoswitching properties of these chromophores at wavelengths up to 625 nm.
Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity
Guglielmi, Paolo,Secci, Daniela,Petzer, Anél,Bagetta, Donatella,Chimenti, Paola,Rotondi, Giulia,Ferrante, Claudio,Recinella, Lucia,Leone, Sheila,Alcaro, Stefano,Zengin, Gokhan,Petzer, Jacobus P.,Ortuso, Francesco,Carradori, Simone
, p. 1511 - 1525 (2019/08/26)
A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPAC/DA)
Use of Phenacyl Thiosalicylates for the Preparation of 3-Hydroxybenzo[ b ]thiophene Derivatives
Trapani, Patricia,Kvapil, Lubomír,Hradil, Pavel,Soural, Miroslav
supporting information, p. 810 - 814 (2018/02/16)
In this work, we attempted to synthesize thioflavonols using rearrangement of phenacyl thiosalicylates prepared by two different approaches and subjected to cyclization under acidic conditions. Contrary to our expectations, the isolated products were iden
Iron-ligand coordination in tandem radical cyclizations: Synthesis of benzo[b]thiophenes by a one-pot reaction of iron 1,3-diketone complexes with 2-thiosalicylic acids
Chan, Sharon Lai-Fung,Low, Kam-Hung,Yang, Chen,Cheung, Samantha Hui-Fung,Che, Chi-Ming
supporting information; experimental part, p. 4709 - 4714 (2011/06/17)
Iron-the mediator: 1,3-Diketone ligands coordinated to iron undergo unprecedented tandem reactions with 2-thiosalicylic acids to give 2-substituted 3-hydroxylbenzo[b]thiophenes in up to 98 % yield. A similar reaction with 2-mercaptonicotinic acid gave a thieno[2,3-b]pyridine derivative in 72 % yield (see scheme). A mechanism involving redox transformation and tandem radical cyclization of the coordinated ligands is proposed. Copyright
