77947-31-0Relevant academic research and scientific papers
Synthesis of imidazopyridines via copper-catalyzed, formal aza-[3 + 2] cycloaddition reaction of pyridine derivatives with α-diazo oxime ethers
Park, Sangjune,Kim, Hyunseok,Son, Jeong-Yu,Um, Kyusik,Lee, Sooho,Baek, Yonghyeon,Seo, Boram,Lee, Phil Ho
, p. 10209 - 10218 (2018/05/31)
The Cu-catalyzed, formal aza-[3 + 2] cycloaddition reaction of pyridine derivatives with α-diazo oxime ethers in trifluoroethanol was used to synthesize imidazopyridines via the release of molecular nitrogen and elimination of alcohol. These methods enabled modular synthesis of a wide range of N-heterobicyclic compounds such as imidazopyridazines, imidazopyrimidines, and imidazopyrazines with an α-imino Cu-carbenoid generated from the α-diazo oxime ethers and copper.
