77956-93-5

Upstream product

• 77956-39-9 3-methylamino-1-benzoxepin-5-(2H)-one 
• 102220-65-5 3-methylamino-3,4-dihydro-1-benzoxepine-5-(2H)-one 
• 62557-53-3 2,3,4,5-tetrahydro-1-benzoxepine-3,5-dione 
• 77956-92-4 methyl 2-(2-acetylphenoxy)acetate 

Downstream Products

• 102220-86-0 (3S,5R)-3-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]oxepin-5-ol; compound with toluene-4-sulfonic acid 
• 102220-86-0 (3R,5R)-3-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]oxepin-5-ol; compound with toluene-4-sulfonic acid 

Relevant academic research and scientific papers

Synthesis of 3-amino-2,3,4,5-tetrahydro-1-benzoxepine-5-ols and their action on gastric motility

3-Amino-2,3,4,5-tetrahydro-1-benzoxepine-5-ols are synthesized by condensation of 2,3,4,5-tetrahydro-1-benzoxepine-3,5-diones with amines and subsequent one or two step reduction. The pharmacological action of these compounds on the gastric motility of anesthetized rats is described. The effects both after parenteral and after enteral application were determined using a pressure recording technique. Dose response curves of KC 2450 (rac. cis-3-methylamino-2,3,4,5-tetrahydro-1-benzoxepine-5-ol hydrochloride; prop. INN for the base: exepanol) and of domperidone are given.