77965-74-3

Upstream product

• 15091-30-2 3,4-dibromo-2,3,4,5-tetrahydrothiophene-1,1-dioxide 
• 2904-57-6 mesitylenecarbonitrile oxide 
• 3001-57-8 3,4-dichlorotetrahydrothiophene-1,1-dioxide 
• 86598-06-3 6-Chloro-3-(2,4,6-trimethyl-phenyl)-3a,5,6,6a-tetrahydro-thieno[2,3-d]isoxazole 4,4-dioxide 
• 86598-07-4 6-Bromo-3-(2,4,6-trimethyl-phenyl)-3a,5,6,6a-tetrahydro-thieno[2,3-d]isoxazole 4,4-dioxide 
• 86597-97-9 Acetic acid 4,4-dioxo-3-(2,4,6-trimethyl-phenyl)-4,5,6,6a-tetrahydro-3aH-4λ⁶-thieno[2,3-d]isoxazol-6-yl ester 
• 70608-16-1 3-(2,4,6-trimethyl-phenyl)-(3ar,6ac)-3a,6a-dihydro-thieno[2,3-d]isoxazole 

Downstream Products

• 77965-77-6 4,4-Dioxo-3-(2,4,6-trimethylphenyl)-5,6-diphenyl-3a,4a,7a,7b-tetrahydroisoxazolidino<2,3-d>thieno<5,6-d'>isoxazoline 
• 77965-76-5 4,4-Dioxo-3,5-bis(2,4,6-trimethylphenyl)-3a,4a,7a,7b-tetrahydrothieno<2,3-d:4,5-d'>diisoxazoline 
• 86598-04-1 3-(2,4,6-Trimethyl-phenyl)-3a,5,6,6a-tetrahydro-thieno[2,3-d]isoxazole 4,4-dioxide 
• 86597-91-3 3,7-Bis-(2,4,6-trimethyl-phenyl)-3a,4a,7a,7b-tetrahydro-thieno[2,3-d;4,5-d']diisoxazole 4,4-dioxide 
• 77965-76-5 3,5-Bis-(2,4,6-trimethyl-phenyl)-3a,4a,7a,7b-tetrahydro-thieno[2,3-d;5,4-d']diisoxazole 4,4-dioxide 

Relevant academic research and scientific papers

SELECTIVITY IN CYCLOADDITIONS-X. REGIOCHEMISTRY OF CYCLOADDITIONS OF NITRILE OXIDES TO THIOPHENE AND BENZOTHIOPHENE 1,1-DIOXIDES

Thiophene-1,1-dioxide undergoes regioselective cycloaddition to benzonitrile oxide.In the reaction with the less reactive mesitonitrile oxide the sulfur dioxide deriving from the dimerization of the dipolarophile causes a catalytic decomposition of the ni

Dipolar Cycloaddition on the Transient Thiophene Sulfone: Isoxazoline and Isoxazolidine Derivatives

From the 3,4-dibromotetrahydrothiophene 1,1-dioxide under basic conditions and in the presence of 1,3 dipoles such as N,α-diphenylnitrone and/or mesitonitrile oxide are obtained isoxazoline and isoxazolidine derivatives of the transient thiophene sulfone as mono- or diadducts.Kinetic studies of the nitrone cycloaddition show a consecutive kinetic scheme of the addition and show that the monoadduct formation is 1E3 faster than that of the diadduct.NMR analysis (1H and 13C) and crystallographic studies show the formation of the adduct where the regioselectivity corresponds to the oxygen atom of the dipoles bonded to the carbon atom β to the sulfone group, the "endo" nature of the addition, and the anti situation of the two rings in the diadduct.