77972-04-4Relevant academic research and scientific papers
2,4-Diaminodihydropyridines (Heterocyclic Compounds, 67. Comm.)
Schweiger, Klaus,Zigeuner, Gustav
, p. 459 - 468 (2007/10/02)
Aminolysis of 4-alkylamino- and 4-dialkylamino-2-methylthiodihydropyridines (*Hl) 1, 2 resp. under various reaction-condition leads to assymmetrically or symmetrically substituted 2,4-bisalkylamino- or 2,4-bisdialkylamino- and 2-alkylamino-4-dialkylamino- or 2-dialkylamino-4-alkylaminodihydropyridines 3, 4, 5, 6 resp.On treatment with alkali only the aminogroup in pos.4 of the pyridines 3, 4, 5, 6 is hydrolyzed and 4-hydroxy-2-aminopyridines 9 are formed.Different substituted 2,4-diaminodihydropyridines 3, 4, 5, 6 can also be synthesized by reaction of 4-hydroxy-2-aminopyridines (*HCl) 9 with amines.Also the aminolysis of 4-alkylamino- and 4-dialkylaminodihydropyridinthiones 7, 8 resp. is described. - Keywords: 2-Alkylamino-4-dialkylamino-5,6-dihydropyridines, synthesis; Alkyl- and arylaminopyridine derivatives, reaction with prim. and sec. amines; Aminolysis of alkyl-, and arylaminopyridine derivatives; 2,4-Bisalkylamino-5,6-dihydropyridines, synthesis; 2,4-Bisdialkylamino-5,6-dihydropyridines, synthesis; 2-Dialkylamino-4-alkylamino-5,6-pyridines, synthesis.
