77982-74-2

Basic information

• Product Name: δ-amino-γ-oxobenzenehexanoic acid hydrochloride
• Synonyms: δ-amino-γ-oxobenzenehexanoic acid hydrochloride
• CAS NO: 77982-74-2
• Molecular Weight: 257.717
• Mol File: 77982-74-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: δ-amino-γ-oxobenzenehexanoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: δ-amino-γ-oxobenzenehexanoic acid hydrochloride(77982-74-2)
• EPA Substance Registry System: δ-amino-γ-oxobenzenehexanoic acid hydrochloride(77982-74-2)

Safety Data

• Hazardous Substances Data: 77982-74-2(Hazardous Substances Data)

Upstream product

• 83084-67-7 2-Phenyl-4-benzyl-4-β-carbomethoxypropionyloxazolone 
• 5874-61-3 4-benzyl-2-phenyl-2-oxazolin-5-one 
• 77982-73-1 (R,S)-5-benzoylamino-4-oxo-6-phenylhexanoic acid methyl ester 
• 83148-55-4 δ-(benzoylamino)-γ-oxobenzenehexanoic acid 

Downstream Products

• 100242-08-8 Boc-Tyr-D-Ala-Phe-CH₂-CH₂-CO-OH 
• 77921-60-9 (S)-1-((S)-5-Acetylamino-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid 
• 99617-49-9 Boc-pGlu-Phe-(RS)Pheψ(COCH2)Gly-Leu-Met-NH2 
• 99604-68-9 pGlu-Phe-(RS)Pheψ(COCH2)Gly-Leu-Met-NH2 
• 99595-03-6 HCl*H-(RS)Pheψ(COCH2)Gly-Leu-Met-NH2 
• 99595-04-7 Boc-(RS)Pheψ(COCH2)Gly-Leu-Met-NH2 
• 100242-12-4 Boc-tyr-D-Ala-Phe-CH₂-CH₂-CO-NH-Ad 
• 100242-09-9 Boc-Tyr-D-Ala-Phe-CH₂-CH₂-CO-OMe 
• 100242-11-3 Boc-Tyr-D-Ala-Phe-CH₂-CH₂-CO-NH₂ 
• 83148-73-6 δ-(acetylamino)-γ-oxobenzenehexanoic acid 
• 99630-61-2 6-phenyl-5-<(tert-butoxycarbonyl)amino>-4-oxohexanoic acid 
• 83450-73-1 (S)-1-((S)-5-Decanoylamino-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid 
• 83509-06-2 (S)-1-((S)-5-Octanoylamino-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid 

Relevant articles and documents

Ketomethylene pseudopeptide analogues of substance P: Synthesis and biological activity

-

Derivatives of the potent angiotensin converting enzyme inhibotor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline: Effect of changes at positions 2 and 5 of the hexanoic acid portion

Several derivatives of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline (1) were synthesized and tested for converting enzyme inhibition activity and blood pressure lowering effects in rats. One compound, 5(S)-benzamido-2(R)-methyl-4-oxo-6-phenylhexanoyl-L-proline (2a), had an I50 against angiotensin converting enzyme of 1.0 x 10-9 M and is the most potent inhibitor prepared thus far in this class of compounds. Testing of 2a orally at 30 mg/kg for inhibition of the angiotensin I induced blood pressure increase in conscious normotensive rats gave 100% inhibition that required 143 min before the angiotensin I blood pressure response returned to 70% of the pretreatment control response. In the conscious renal hypertensive rat, 2a given orally at a dose of 3 mg/kg caused a lowering of blood pressure that reached its maximum of 40 mmHg 8 h following drug administration.